ReviewJournal of neurochemistry2024
Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review.
Review in Journal of neurochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Early axonal degeneration linked to clinical decline in Alzheimer's disease progression revealed with diffusion MRI.The Journal of clinical investigation · 2026Trial
- MRI-Based Quantitative Assessment of Normal-Appearing White and Gray Matter Demyelination in Multiple Sclerosis, Parkinson's Disease, Long COVID, and Normal Aging.Biomedicines · 2026Article
- MC BTS: Simultaneously Resolving Magnetization Transfer Effect and Relaxation for Multiple Components.Magnetic resonance in medicine · 2026Article
- Multi-omics validation of myelin water fraction as a myelin-specific MRI biomarker.NeuroImage · 2026Article
- Article
- Excess iron in deep gray matter is associated with cognitive and functional decline: The mediating role of white matter myelin.NeuroImage · 2026Article
- Age-related differences in choroid plexus structural integrity are associated with changes in cognition.Fluids and barriers of the CNS · 2025Article
- Multimodal MR imaging for quantification of brain lipid in mice at 9.4T.Journal of translational medicine · 2025Article
- Sustained breastfeeding associations with brain structure and cognition from late childhood to early adolescence.Pediatric research · 2025Article
- Quantitative MRI in Neuroimaging: A Review of Techniques, Biomarkers, and Emerging Clinical Applications.Brain sciences · 2025Review
- Multimodal MR Imaging for quantification of brain lipid in mice at 9.4T.bioRxiv : the preprint server for biology · 2025Article
- Multivariate White Matter Microstructure Alterations in Older Adults with Coronary Artery Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Multi-Omics Validation of Myelin Water Fraction as a Myelin-Specific MRI Biomarker.medRxiv : the preprint server for health sciences · 2025Article
- Axonal Degeneration Across the Alzheimer's Disease Spectrum: A Longitudinal MRI and Fluid Biomarker Study.medRxiv : the preprint server for health sciences · 2025Article
- Three-Dimensional Efficient Myelin-Weighted Imaging Utilizing Direct Visualization of Short Transverse Relaxation Time Component (ViSTa).Human brain mapping · 2025Article
- Article
- Age-related differences in Rostral-Middle locus coeruleus microstructure: A critical role in cognitive decline revealed by magnetic resonance relaxometry.Alzheimer's research & therapy · 2025Article
- Investigating the association between human brainstem microstructural integrity and hypertension using magnetic resonance relaxometry.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation.International journal of molecular sciences · 2025Review
- Age-Related Differences in the Choroid Plexus Structural Integrity Are Associated with Changes in Cognition.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance imaging (MRI) biomarker for investigating brain function and composition. This comprehensive review synthesizes the current state of knowledge on MWF as a biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination. The databases used include Web of Science, Scopus, Science Direct, and PubMed. We begin with a brief discussion of the theoretical foundations of MWF imaging, including its basis in MR physics and the mathematical modeling underlying its calculation, with an overview of the most adopted MRI methods of MWF imaging. Next, we delve into the clinical and research applications that have been explored to date, highlighting its advantages and limitations. Finally, we explore the potential of MWF to serve as a predictive biomarker for neurological disorders and identify future research directions for optimizing MWF imaging protocols and interpreting MWF in various contexts. By harnessing the power of MWF imaging, we may gain new insights into brain health and disease across the human lifespan, ultimately informing novel diagnostic and therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.