Evidence map›Paper›PMID 38976288›Full record

ArticleBiomaterials science2024

Unnatural lipids for simultaneous mRNA delivery and metabolic cell labeling.

Yusheng Liu, Jiadiao Zhou, Yueji Wang, Dhyanesh Baskaran, Hua Wang

Abstract read
In one paragraph

Article in Biomaterials science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yusheng LiuDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. huawang3@illinois.edu.
Jiadiao ZhouDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. huawang3@illinois.edu.
Yueji WangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. huawang3@illinois.edu.
Dhyanesh BaskaranDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. huawang3@illinois.edu.
Hua WangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. huawang3@illinois.edu.ORCID http://orcid.org/0000-0002-1157-8786

Funding

Biomaterials for Targeted Modulation of Conventional Type 1 Dendritic CellsR01CA274738 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WANG, HUA · 2022 to 2025
$2.2M
Metabolic tagging of tumor exosomes for developing enhanced exosome vaccinesR21CA270872 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WANG, HUA · 2023 to 2024
$364k
NCI NIH HHS R01 CA274738NCI NIH HHS R21 CA270872
6 · The paper itself

Abstract

Lipids have demonstrated tremendous promise for mRNA delivery, as evidenced by the success of Covid-19 mRNA vaccines. However, existing lipids are mostly used as delivery vehicles and lack the ability to monitor and further modulate the target cells. Here, for the first time, we report a class of unnatural lipids (azido-DOTAP) that can efficiently deliver mRNAs into cells and meanwhile metabolically label cells with unique chemical tags (

Indexed as

AzidesClick ChemistryRNA, MessengerAnimalsCOVID-19Dendritic CellsFatty Acids, MonounsaturatedHumansLipidsQuaternary Ammonium CompoundsSARS-CoV-2Transfection1,2-dioleoyloxy-3-(trimethylammonium)propaneAzidesFatty Acids, MonounsaturatedLipidsQuaternary Ammonium CompoundsRNA, Messenger

Identifiers

PMID38976288
PMCPMC11303094

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.