Evidence map›Paper›PMID 38976500›Full record

ArticleeLife2024

Chemoproteomics validates selective targeting of

Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie Counihan and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Advances in Anthelmintic Target Identification.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Carlo Giannangelo *Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.ORCID https://orcid.org/0000-0002-6654-7266
Matthew P Challis *Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Ghizal SiddiquiDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Rebecca EdgarSchool of Medicine, Deakin University, Geelong, Australia.
Tess R MalcolmMonash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Chaille T WebbMonash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Nyssa DrinkwaterMonash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Natalie VinhMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Christopher MacraildDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Natalie CounihanSchool of Medicine, Deakin University, Geelong, Australia.ORCID https://orcid.org/0000-0002-8973-3344
Sandra DuffyDiscovery Biology, Centre for Cellular Phenomics, Griffith University, Nathan, Australia.
Sergio WittlinSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Shane M DevineThe Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.ORCID https://orcid.org/0000-0001-8727-7392
Vicky M AveryDiscovery Biology, Centre for Cellular Phenomics, Griffith University, Nathan, Australia.
Tania De Koning-WardSchool of Medicine, Deakin University, Geelong, Australia.
Peter ScammellsMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Sheena McGowanMonash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.ORCID https://orcid.org/0000-0001-6863-1106
Darren J CreekDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.ORCID https://orcid.org/0000-0001-7497-7082

Funding

National Health and Medical Research Council APP1150359National Health and Medical Research Council APP1185354
6 · The paper itself

Abstract

New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of

Indexed as

AntimalarialsPlasmodium falciparumPlasmodium vivaxProteomicsProtozoan ProteinsAminopeptidasesHumansAminopeptidasesAntimalarialsProtozoan Proteinsaminopeptidasebiochemistrychemical biologychemoproteomicsdrug targetinfectious diseasemalariamass spectrometrymetabolomicsmicrobiologyP. falciparum

Identifiers

PMID38976500
PMCPMC11230628

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.