Evidence map›Paper›PMID 38977342›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Recombinant

L Lu, X Yang, H Zhang, Y Liang, X Shi, X Zhou

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

L LuDepartment of Pathology and Physiology, Shanxi Medical University, Taiyuan 030002, China.
X YangDepartment of Human Parasitology, Anhui Provincial Key Laboratory of Infection and Immunology, Bengbu Medical University, Bengbu 233030, China.
H ZhangDepartment of Medical Laboratory, Hebi Vocational and Technical College, Hebi 458030, China.
Y LiangDepartment of Pathology and Physiology, Shanxi Medical University, Taiyuan 030002, China.
X ShiDepartment of Endoscopy, Taiyuan Third People's Hospital, Taiyuan 030012, China.
X ZhouDepartment of Pathology and Physiology, Shanxi Medical University, Taiyuan 030002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the protective effect of recombinant

methodsAdult male C57BL/6J mice with or without LPS/D-GaIN-induced acute liver injury were given intraperitoneal injections of rSj-Cys or PBS 30 min after modeling (

resultsThe survival rates of PBS- and rSj-Cys-treated mouse models of acute liver injury were 30% and 80% at 12 h and were 10% and 60% at 24 h after modeling, respectively; no death occurred in the two control groups within 24 h. The mouse models showed significantly increased serum levels of AST, ALT, IL-6 and TNF-α and serious liver pathologies with increased hepatic expressions of CD68 and Bax, lowered expression of Bcl-2, increased hepatocyte apoptosis, and up-regulated expressions of ERS-related signaling pathway proteins GRP78, CHOP and NF-κB p-p65. Treatment of the mouse models significantly lowered the levels of AST, ALT, IL-6 and TNF-α, alleviated liver pathologies, reduced hepatic expressions of CD68, Bax, GRP78, CHOP and NF-κB p-p65, and enhanced the expression of Bcl-2. In the normal control mice, rSj-Cys injection did not produce any significant changes in these parameters compared with PBS.

conclusionrSj-Cys alleviates LPS/D-GalN-induced acute liver injury in mice by suppressing ERS, attenuating inflammation and inhibiting hepatocyte apoptosis.

Indexed as

ApoptosisCystatinsEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressHepatocytesInflammationMice, Inbred C57BLSchistosoma japonicumAnimalsAntigens, CDAntigens, Differentiation, Myelomonocyticbcl-2-Associated X ProteinCD68 MoleculeChemical and Drug Induced Liver InjuryGalactosamineInterleukin-6Antigens, CDAntigens, Differentiation, Myelomonocyticbcl-2-Associated X ProteinCD68 MoleculeCD68 protein, mouseCystatinsEndoplasmic Reticulum Chaperone BiPGalactosamineHspa5 protein, mouseInterleukin-6LipopolysaccharidesProto-Oncogene Proteins c-bcl-2Recombinant ProteinsTumor Necrosis Factor-alphaacute liver injuryapoptosisendoplasmic reticulum stressinflammatory responseSchistosoma japonicum cystatin

Identifiers

PMID38977342
PMCPMC11237295

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.