Evidence map›Paper›PMID 38977641›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2024

IL-18BP Therapy Ameliorates Reproductive and Metabolic Phenotypes in a PCOS Mouse Model by Relieving Inflammation, Fibrosis and Endoplasmic Reticulum Stress.

Yixuan Bai, Yan Liu, Yuhui Wang, Xitong Liu, Yang Wang, Haiou Liu, Huan Yi, Congjian Xu, Feifei Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yixuan Bai *Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Yan Liu *Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Yuhui WangObstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Xitong LiuObstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Yang WangObstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Haiou LiuObstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Huan YiNational Key Gynecology Clinical Specialty Construction Unit of China, Fujian Maternity and Child Health Hospital, Fuzhou, China. yihuangsrk@126.com.
Congjian XuObstetrics and Gynecology Hospital, Fudan University, Shanghai, China. xucongjian@fudan.edu.cn.
Feifei ZhangObstetrics and Gynecology Hospital, Fudan University, Shanghai, China. feifeizhang@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a chronic inflammation in PCOS patients, which is correlated with the pathogenesis of PCOS. IL-18 and IL-18BP are related with some inflammatory diseases, while less explored in PCOS. Whether IL-18BP could be a potential drug of PCOS remains unknown.IL-18 and testosterone levels were evaluated in serum of 10 non-PCOS control patients and 20 PCOS patients. Female C57/BL6 mice were gavaged with letrozole to induce PCOS mouse model and IL-18 level was evaluated in the serum of PCOS mouse model, and IL-18 is intraperitoneally injected in female mice, IL-18BP is intraperitoneally injected in the PCOS mice models. Then the body weights, estrous cycles, reproductive hormones and morphology of ovaries were analyzed. The level of ovarian chronic inflammation, fibrosis and endoplasmic reticulum (ER) stress are evaluated.IL-18 levels are increased in the serum of PCOS patients and PCOS mice models respectively. The serum DHEAS, iWAT weight and adipocyte size were increased in IL-18 group compared to the control group (P < 0.05). In the PCOS mouse model treated with IL-18BP, the body weight and serum LH/FSH ratio was decreased compared to the PCOS group (P < 0.05). The expression levels of inflammatory factors and fibrosis-related genes, the expression level of endoplasmic reticulum stress-related genes, and the ROS positive area of ovarian tissue was decreased (P < 0.05).IL-18 is involved in inducing PCOS phenotypes, while IL-18BP relieves PCOS phenotypes by alleviating ovarian chronic inflammation, fibrosis and ER stress in PCOS mice.

Indexed as

Disease Models, AnimalEndoplasmic Reticulum StressFibrosisInflammationInterleukin-18Polycystic Ovary SyndromeAdultAnimalsFemaleHumansIntercellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLOvaryPhenotypeReproductionIntercellular Signaling Peptides and ProteinsInterleukin-18interleukin-18 binding proteinTestosteroneFibrosisIL-18InflammationPCOS

Identifiers

PMID38977641

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.