Evidence map›Paper›PMID 38977718›Full record

ArticleScientific reports2024

Metagenomic comparison of intestinal microbiota between normal and liver fibrotic rhesus macaques (Macaca mulatta).

Yuankui Wei, Junhui Li, Baoqiang Zhu, Qi Hu, Ming Lan, Jia Zhou, Jianbo Luo, Wanlong Zhu, Yong Lai, Enwu Long and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Isolation and characterization ofFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuankui Wei *School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Junhui Li *Departmemt of Institute of Laboratory Animal Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Baoqiang Zhu *Department of Pharmacy, 363 Hospital, Chengdu, Sichuan, China.
Qi HuInstitute of Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Ming LanDepartmemt of Institute of Laboratory Animal Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Jia ZhouDepartmemt of Institute of Laboratory Animal Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Jianbo LuoDepartmemt of Institute of Laboratory Animal Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Wanlong ZhuDepartment of Pharmacy, The Second People's Hospital of Panzhihua, Panzhihua, Sichuan, China.
Yong LaiSchool of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Enwu LongSchool of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China. dragon984169@126.com.
Liang ZhouDepartmemt of Institute of Laboratory Animal Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. 328382837@qq.com.

Funding

Science & Technology Department of Sichuan Province 2022JDZH0014
6 · The paper itself

Abstract

Liver fibrosis is an important pathological process in chronic liver disease and cirrhosis. Recent studies have found a close association between intestinal microbiota and the development of liver fibrosis. To determine whether there are differences in the intestinal microbiota between rhesus macaques with liver fibrosis (MG) and normal rhesus macaques (MN), fecal samples were collected from 8 male MG and 12 male MN. The biological composition of the intestinal microbiota was then detected using 16S rRNA gene sequencing. The results revealed statistically significant differences in ASVs and Chao1 in the alpha-diversity and the beta-diversity of intestinal microbiota between MG and MN. Both groups shared Prevotella and Lactobacillus as common dominant microbiota. However, beneficial bacteria such as Lactobacillus were significantly less abundant in MG (P = 0.02). Predictive functional analysis using PICRUSt2 gene prediction revealed that MG exhibited a higher relative abundance of functions related to substance transport and metabolic pathways. This study may provide insight into further exploration of the mechanisms by which intestinal microbiota affect liver fibrosis and its potential future use in treating liver fibrosis.

Indexed as

Gastrointestinal MicrobiomeLiver CirrhosisMacaca mulattaMetagenomicsRNA, Ribosomal, 16SAnimalsBacteriaFecesMaleMetagenomeRNA, Ribosomal, 16S16S rRNA gene sequencingIntestinal microbiotaLiver fibrosisMacaca mulattaMetagenomicRhesus macaques

Identifiers

PMID38977718
PMCPMC11231266

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.