ArticleScientific reports2024
Empagliflozin rescues pro-arrhythmic and Ca
Abstract read
In one paragraph
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Redefining outcomes of ventricular arrhythmia for SGLT2 inhibitor medication in heart failure patients: a meta-analysis of randomized controlled trials.Systematic reviews · 2025Pooled it
- Dynamic alterations in cardiac autonomic regulation during recurrent generalized seizures.iScience · 2026Article
- Empagliflozin restores cardiac function in obese-diabetic HFpEF mice but further alters gene expression.Basic research in cardiology · 2026Article
- Emerging Role of Sodium-Glucose Cotransporter-2 Inhibitors in Aortic Stenosis.JACC. Basic to translational science · 2026Review
- Optical mapping: pioneering the frontier of preclinical antiarrhythmic drug evaluation.iScience · 2026Review
- Molecular Mechanisms and Therapeutic Strategies in Heart Failure Due to Dystrophin Deficiency: A Comprehensive Review.Reviews in cardiovascular medicine · 2026Review
- The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac NaAmerican journal of physiology. Heart and circulatory physiology · 2025Article
- Sodium-Glucose Cotransporter 2 Inhibitors in Aortic Stenosis: Toward a Comprehensive Cardiometabolic Approach.International journal of molecular sciences · 2025Review
- Proarrhythmic Lipid Inflammatory Mediators: Mechanisms in Obesity Arrhythmias.Journal of cellular physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Qiang Wen *Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Rd, Wuhan, 430022, Hubei Province, China.
Rui Zhang *Key Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Kejun YeKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Jun YangKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Hangchuan ShiDepartment of Clinical & Translational Research, University of Rochester Medical Center, 265 Crittenden Blvd, Rochester, NY, 14642, USA.
Zhu LiuKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Yangpeng LiKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Ting LiuKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Shiyu ZhangKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Wanpei ChenKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Jingjing WuDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Rd, Wuhan, 430022, Hubei Province, China.
Weichao LiuKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Xiaoqiu TanKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Ming LeiKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China.
Christopher L-H HuangKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China. clh11@cam.ac.uk.
Xianhong OuKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, 1 Xianglin Rd, Luzhou, 646000, Sichuan Province, China. oxh8081@swmu.edu.cn.
Funding
British Heart Foundation PG/14/79/31102British Heart Foundation PG/21/10512High Talents Plan, Peoples Republic of China 2021JDGD0047National Natural Science Foundation of China 81700308National Natural Science Foundation of China 81900300Sichuan Province Science and Technology Support Program 221YYJC1944State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) CMEMR2017-B08
Abstract
We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2-6 weeks) challenge resulted in reduced late Na
Indexed as
Benzhydryl CompoundsCalciumGlucosidesHomeostasisAction PotentialsAnimalsAortaArrhythmias, CardiacDisease Models, AnimalIsoproterenolMaleMiceMice, Inbred C57BLMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelSodium-Calcium ExchangerBenzhydryl CompoundsCalciumempagliflozinGlucosidesIsoproterenolNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mouseSodium-Calcium ExchangerSodium-Glucose Transporter 2 InhibitorsAction potential durationCa2+ homeostasisEmpagliflozinHeart failureTransverse aortic constriction (TAC)Ventricular arrhythmia
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.