Evidence map›Paper›PMID 38979232›Full record

ArticlebioRxiv : the preprint server for biology2024

Loss of TDP-43 induces synaptic dysfunction that is rescued by

Matthew J Keuss, Peter Harley, Eugeni Ryadnov, Rachel E Jackson, Matteo Zanovello, Oscar G Wilkins, Simone Barattucci, Puja R Mehta, Marcio G Oliveira, Joanna E Parkes and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Matthew J KeussUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.ORCID 0000-0002-2628-4115
Peter HarleyUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.ORCID 0000-0001-6689-0227
Eugeni RyadnovUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.ORCID 0009-0003-9921-1755
Rachel E JacksonCentre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London; London SE1 1UL, UK.ORCID 0000-0001-9454-0080
Matteo ZanovelloUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.ORCID 0000-0003-3343-1547
Oscar G WilkinsUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.ORCID 0000-0002-3334-0568
Simone BarattucciUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.
Puja R MehtaUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.ORCID 0000-0002-0255-407X
Marcio G OliveiraCentre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London; London SE1 1UL, UK.
Joanna E ParkesNucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK.ORCID 0000-0002-4007-240X
Aparna SinhaNucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK.ORCID 0000-0001-5184-1326
Andrés F Correa-SánchezNucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK.ORCID 0000-0003-1423-3449
Peter L OliverNucleic Acid Therapy Accelerator; Harwell, Didcot OX11 0FA, UK.ORCID 0000-0003-3347-2461
Elizabeth M C FisherUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.ORCID 0000-0003-2850-9936
Giampietro SchiavoUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.ORCID 0000-0002-4319-8745
Mala ShahDepartment of Pharmacology, School of Pharmacy, University College London; London, WC1N 4AX, UK.ORCID 0000-0002-8323-4739
Juan BurroneCentre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London; London SE1 1UL, UK.ORCID 0000-0003-1233-668X
Pietro FrattaUCL Queen Square Motor Neuron Disease Centre and Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London; London, WC1N 3BG, UK.ORCID 0000-0002-7554-1632

Funding

Human Biomarkers CoreU54NS123743 · NINDS · STANFORD UNIVERSITY · PI FRATTA, PIETRO, GITLER, AARON D. · 2021 to 2025
$8.2M
NINDS NIH HHS U54 NS123743Wellcome Trust
6 · The paper itself

Abstract

TDP-43 loss of function induces multiple splicing changes, including a cryptic exon in the amyotrophic lateral sclerosis and fronto-temporal lobar degeneration risk gene

Identifiers

PMID38979232
PMCPMC11230273

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.