Evidence map›Paper›PMID 38979360›Full record

ArticlebioRxiv : the preprint server for biology2024

NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion.

Michael S Dahabieh, Lisa M DeCamp, Brandon M Oswald, Susan M Kitchen-Goosen, Zhen Fu, Matthew Vos, Shelby E Compton, Joseph Longo, Kelsey S Williams, Abigail E Ellis and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Michael S DahabiehDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Lisa M DeCampDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Brandon M OswaldDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Susan M Kitchen-GoosenDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Zhen FuBioinformatics and Biostatistics Core Facility, Van Andel Institute, Grand Rapids, MI, USA.
Matthew VosDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Shelby E ComptonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Joseph LongoDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Kelsey S WilliamsDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Abigail E EllisMass Spectrometry Core Facility, Van Andel Institute, Grand Rapids, MI, USA.
Amy JohnsonMass Spectrometry Core Facility, Van Andel Institute, Grand Rapids, MI, USA.
Ibukunoluwa SodiyaDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Michael VincentDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Hyoungjoo LeeDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Ryan D SheldonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Connie M KrawczykDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-2468-5986
Chen YaoDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tuoqi WuDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Russell G JonesDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.

Funding

Ketone Body Metabolism in CD8+ T Cell ResponsesR01AI165722 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI JONES, RUSSELL GRAHAM · 2022 to 2025
$3.3M
Program stem-like CD8 T cells to enhance antiviral immunity against chronic viral infectionR01AI158294 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Tuoqi Wu · 2022 to 2026
$2.9M
Harnessing Stem-Like CD8 T Cells for Immunotherapies to Eradicate HIV ReservoirsDP2AI154450 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI YAO, CHEN · 2021 to 2025
$2.5M
Rejuvenating aged T cell immunity by targeting stem cell-like CD8 T cellsR00AG056524 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI WU, TUOQI · 2019 to 2021
$733k
Chromatin architecture as a determinant of dendritic cell functionR21AI153997 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI KRAWCZYK, CONNIE · 2020 to 2021
$523k
NIAID NIH HHS DP2 AI154450NIAID NIH HHS R01 AI158294NIAID NIH HHS R01 AI165722NIAID NIH HHS R21 AI153997NIA NIH HHS K99 AG056524NIA NIH HHS R00 AG056524
6 · The paper itself

Abstract

The progressive decline of CD8 T cell effector function-also known as terminal exhaustion-is a major contributor to immune evasion in cancer. Yet, the molecular mechanisms that drive CD8 T cell dysfunction remain poorly understood. Here, we report that the Kelch-like ECH-associated protein 1 (KEAP1)-Nuclear factor erythroid 2-related factor 2 (NRF2) signaling axis, which mediates cellular adaptations to oxidative stress, directly regulates CD8 T cell exhaustion. Transcriptional profiling of dysfunctional CD8 T cells from chronic infection and cancer reveals enrichment of NRF2 activity in terminally exhausted (Tex

Identifiers

PMID38979360
PMCPMC11230227

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.