Evidence map›Paper›PMID 38979792›Full record

ArticleJournal of the American Heart Association2024

Peritoneal Dialysis Aggravates and Accelerates Atherosclerosis in Uremic

Jamie Kane, Winnie G Vos, Laura A Bosmans, Bram W van Os, Myrthe den Toom, Sanne Hoeksema-Hackmann, Denise Moen-de Wit, Marion J Gijbels, Linda Beckers, Aldo Grefhorst and 5 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jamie KaneDepartment of Nephrology, Amsterdam Cardiovascular Sciences Amsterdam University Medical Centre Amsterdam the Netherlands.ORCID 0009-0005-0129-0075
Winnie G VosDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Immunity and Infection Amsterdam University Medical Centre Amsterdam the Netherlands.ORCID 0000-0001-7805-7275
Laura A BosmansDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Immunity and Infection Amsterdam University Medical Centre Amsterdam the Netherlands.ORCID 0000-0002-1984-9691
Bram W van OsDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Immunity and Infection Amsterdam University Medical Centre Amsterdam the Netherlands.
Myrthe den ToomDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Immunity and Infection Amsterdam University Medical Centre Amsterdam the Netherlands.
Sanne Hoeksema-HackmannAnimal Research Institute AMC Amsterdam University Medical Centre Amsterdam the Netherlands.
Denise Moen-de WitAnimal Research Institute AMC Amsterdam University Medical Centre Amsterdam the Netherlands.
Marion J GijbelsDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Immunity and Infection Amsterdam University Medical Centre Amsterdam the Netherlands.ORCID 0000-0002-4906-0384
Linda BeckersDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Immunity and Infection Amsterdam University Medical Centre Amsterdam the Netherlands.
Aldo GrefhorstDepartment of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences Amsterdam University Medical Centre Amsterdam the Netherlands.ORCID 0000-0003-1761-9494
Johannes H M LevelsDepartment of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences Amsterdam University Medical Centre Amsterdam the Netherlands.ORCID 0000-0002-8946-8819
Lily JakuljDepartment of Nephrology, Amsterdam Cardiovascular Sciences Amsterdam University Medical Centre Amsterdam the Netherlands.ORCID 0000-0002-8678-682X
Marc G VervloetDepartment of Nephrology, Amsterdam Cardiovascular Sciences Amsterdam University Medical Centre Amsterdam the Netherlands.ORCID 0000-0003-4607-9415
Esther LutgensDepartment of Cardiovascular Medicine and Immunology Mayo Clinic Rochester MN.ORCID 0000-0002-2609-5744
Etto C EringaDepartment of Physiology, Amsterdam Cardiovascular Sciences Amsterdam University Medical Centre Amsterdam the Netherlands.ORCID 0000-0002-9814-5149

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtherosclerosis is highly prevalent in people with chronic kidney disease (CKD), including those receiving peritoneal dialysis (PD). Although it is lifesaving, PD induces profound systemic inflammation, which may aggravate atherosclerosis. Therefore, the hypothesis is that this PD-induced inflammation aggravates atherosclerosis via immune cell activation. METHODS AND

results

conclusionsPD-fluid exposure in uremic mice potentiates systemic and vascular T-cell-driven inflammation and aggravates atherosclerosis. PD polarized CD4

Indexed as

AtherosclerosisDisease Models, AnimalPeritoneal DialysisRenal Insufficiency, ChronicUremiaAnimalsApolipoproteins EMaleMiceMice, Inbred C57BLMice, Knockout, ApoENephrectomyPlaque, AtheroscleroticApolipoproteins Eatherosclerosischronic kidney diseaseinflammationkidney replacement therapyperitoneal dialysis

Identifiers

PMID38979792
PMCPMC11292770

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.