Evidence map›Paper›PMID 38980080›Full record

ArticleThe Journal of comparative neurology2024

ABC Efflux Transporters and Solute Carriers in the Early Developing Brain of a Marsupial Monodelphis domestica (South American Gray Short-Tailed Opossum).

Yifan Huang, Katarzyna M Dziegielewska, Mark D Habgood, Fiona Qiu, Ana C C Leandro, Paul D Callaghan, Joanne E Curran, John L VandeBerg, Norman R Saunders

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of comparative neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yifan HuangDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-1060-3668
Katarzyna M DziegielewskaDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Mark D HabgoodDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Fiona QiuDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Ana C C LeandroDivision of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, Texas, USA.
Paul D CallaghanANSTO-Australia's Nuclear Science and Technology Organisation, Lucas Heights, New South Wales, Australia.
Joanne E CurranDivision of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, Texas, USA.
John L VandeBergDivision of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, Texas, USA.
Norman R SaundersDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.

Funding

Construction of a Biomedical Research Facility at the U*C06RR020547 · NCRR · UNIV/TEXAS BROWNSVILLE & SOUTHMOST COLL · PI KROUSE, JOHN H · 2010 to 2010
$4.0M
Funding provided by Katarzyna M Dziegielewska and Norman R SaundersNCRR NIH HHS C06 RR020547NIH HHS C06 RR020547
6 · The paper itself

Abstract

This study used a marsupial Monodelphis domestica, which is born very immature and most of its development is postnatal without placental protection. RNA-sequencing (RNA-Seq) was used to identify the expression of influx and efflux transporters (ATP-binding cassettes [ABCs] and solute carriers [SLCs]) and metabolizing enzymes in brains of newborn to juvenile Monodelphis. Results were compared to published data in the developing eutherian rat. To test the functionality of these transporters at similar ages, the entry of paracetamol (acetaminophen) into the brain and cerebrospinal fluid (CSF) was measured using liquid scintillation counting following a single administration of the drug along with its radiolabelled tracer [

Indexed as

ATP-Binding Cassette TransportersBrainMonodelphisAcetaminophenAnimalsAnimals, NewbornFemaleRatsSolute Carrier ProteinsAcetaminophenATP-Binding Cassette TransportersSolute Carrier ProteinsABC efflux transporterbrain developmentMonodelphis domesticaparacetamolplacentaratRRID:NCBITaxon_13616RRID:SCR_002344RRID:SCR_006281SLC transporter

Identifiers

PMID38980080
PMCPMC11257411

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.