Evidence map›Paper›PMID 38980653›Full record

ArticleJournal of cardiovascular translational research2024

TMAO Impairs Mouse Aortic Vasodilation by Inhibiting TRPV4 Channels in Endothelial Cells.

Ning Zhang, Liangju Liu, Xiaowang Lv, Yixuan Wang, Wei Zhang, Xin Wen, Fan Yu, Tingting Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ning Zhang *Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
Liangju Liu *Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
Xiaowang LvWuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
Yixuan WangWuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
Wei ZhangWuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
Xin WenWuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
Fan YuWuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
Tingting ZhouWuxi School of Medicine, Jiangnan University, Wuxi, 214122, China. tingtingchou@jiangnan.edu.cn.ORCID 0009-0002-4093-3414

Funding

Fundamental Research Funds for the Central Universities JUSRP12047National Natural Science Foundation of China 81800430National Natural Science Foundation of China 82200463
6 · The paper itself

Abstract

Trimethylamine oxide (TMAO) is an intestinal flora metabolite associated with risk of cardiovascular diseases. Transient receptor potential vanilloid 4 (TRPV4) is a Ca

Indexed as

AortaCalcium SignalingEndothelial CellsMethylaminesMice, Inbred C57BLTRPV Cation ChannelsVasodilationAnimalsCells, CulturedDose-Response Relationship, DrugHumansMaleMembrane PotentialsMiceSignal TransductionMethylaminestrimethyloxamineTrpv4 protein, mouseTRPV Cation ChannelsEndothelial cellTrimethylamine oxideTRPV4Vasodilatation

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.