Evidence map›Paper›PMID 38980969›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2024

Risk factors for severe outcomes of coronavirus disease 2019 through the waves of the pandemic: Comparing patients with and without solid organ transplantation.

Stephen B Lee, Ran Dai, Evan French, Jerrod A Anzalone, Amy L Olex, Jin Ge, Makayla Schissel, Gaurav Agarwal, Amanda Vinson, Vithal Madhira and 2 more

Abstract readComparative Study
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stephen B LeeDepartment of Medicine, Division of Infectious Diseases, University of Saskatchewan, Regina, Canada.ORCID https://orcid.org/0000-0002-6253-293X
Ran DaiDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Evan FrenchVirginia Commonwealth University Wright Center for Clinical and Translational Research, Richmond, Virginia, USA.
Jerrod A AnzaloneDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Amy L OlexVirginia Commonwealth University Wright Center for Clinical and Translational Research, Richmond, Virginia, USA.
Jin GeDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California, San Francisco, California, USA.
Makayla SchisselDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Gaurav AgarwalDepartment of Internal Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Amanda VinsonDepartment of Medicine, Division of Nephrology, Dalhousie University, Halifax, Canada.
Vithal MadhiraPalila Software, Reno, Nevada, USA.
Roslyn B MannonDepartment of Internal Medicine, Division of Nephrology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
N3C Consortium

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, YING · 2016 to 2025
$42.8M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Wright Regional Center for Clinical and Translational ScienceUM1TR004360 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI FREDERICK Gerard MOELLER · 2023 to 2026
$16.3M
A pragmatic RCT to evaluate the effect of CirrhosisRx, a novel clinical decision support system, versus usual care on guideline-adherence and clinical outcomes for patients with cirrhosisK23DK139455 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jin Ge · 2024 to 2026
$569k
CTSA UL1TR002649NCATS NIH HHS KL2 TR001870NCATS NIH HHS KL2TR001870NCATS NIH HHS UL1 TR002649NCATS NIH HHS UM1 TR004360NIDDK NIH HHS K23 DK139455NIDDK NIH HHS P30 DK026743NIGMS NIH HHS U54 GM104942NIGMS NIH HHS U54GM104942NIGMS NIH HHS U54 GM115458NIGMS NIH HHS U54GM115458UCSF Liver Center P30DK026743
6 · The paper itself

Abstract

backgroundWhile coronavirus disease 2019 (COVID-19) is no longer a public health emergency, certain patients remain at risk of severe outcomes. To better understand changing risk profiles, we studied the risk factors for patients with and without solid organ transplantation (SOT) through the various waves of the pandemic.

methodsUsing the National COVID Cohort Collaborative we studied a cohort of adult patients testing positive for COVID-19 between January 1, 2020, and May 2, 2022. We separated the data into waves of COVID-19 as defined by the Centers for Disease Control. In our primary outcome, we used multivariable survival analysis to look at various risk factors for hospitalization in those with and without SOT.

resultsA total of 3,570,032 patients were captured. We found an overall risk attenuation of adverse COVID-19-associated outcomes over time. In both non-SOT and SOT populations, diabetes, chronic kidney disease, and congestive heart failure were risk factors for hospitalization. For SOT specifically, longer time periods between transplant and COVID-19 were protective and age was a risk factor. Notably, asthma was not a risk factor for major adverse renal cardiovascular events, hospitalization, or mortality in either group.

conclusionsOur study provides a longitudinal view of the risks associated with adverse COVID-related outcomes amongst SOT and non-SOT patients, and how these risk factors evolved over time. Our work will help inform providers and policymakers to better target high-risk patients.

Indexed as

COVID-19HospitalizationOrgan TransplantationSARS-CoV-2AdultAgedCohort StudiesFemaleHumansMaleMiddle AgedPandemicsRisk FactorsCOVIDCOVID‐19N3CSARS‐CoV‐2solid organ transplantationtransplantation

Identifiers

PMID38980969
PMCPMC11502248

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.