ArticleBMJ (Clinical research ed.)2024
Reporting of surrogate endpoints in randomised controlled trial protocols (SPIRIT-Surrogate): extension checklist with explanation and elaboration.
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Article in BMJ (Clinical research ed.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Article
- Surrogate endpoints in cost-effectiveness analysis for use in health technology assessment - a qualitative analysis.International journal of technology assessment in health care · 2026Article
- Patient and public involvement and engagement in methodology research: process, experiences, and recommendations from the SPIRIT- and CONSORT-Surrogate project.Research involvement and engagement · 2025Article
- Recommended methodologies for clinical investigations of high-risk medical devices-Conclusions from the European Union CORE-MD Project.The Lancet regional health. Europe · 2025Review
- A Strategic Roadmap to Support Communication on and Acceptance of Surrogate Endpoints: The REnal Surrogacy accEpTance in Chronic Kidney Disease (RESET CKD) Collaboration.Advances in therapy · 2025Article
- Use of surrogate endpoints in health technology assessment and reimbursement of treatments for the management of chronic kidney disease.EClinicalMedicine · 2025Review
- The state of mechanistic research in the evidence-based medicine era: A sandwalk between triangulation and hierarchies.Experimental physiology · 2025Article
- Role of prespecified analysis plans in physiological research: Encouraged or mandatory?Experimental physiology · 2025Article
- A call for transparency, improved reporting, and interpretation of trials using surrogate end points in cardiac electrophysiology.Heart rhythm · 2025Review
- Development of START-EDI guidelines for reporting equality, diversity and inclusion in research: a study protocol.BMJ open · 2025Article
- SPIRIT 2025 statement: updated guideline for protocols of randomized trials.Nature medicine · 2025Review
- Protocol Development for Investigator-Sponsored Clinical Studies.Clinical and translational science · 2025Article
- SPIRIT 2025 statement: updated guideline for protocols of randomised trials.BMJ (Clinical research ed.) · 2025Article
- SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials.BMJ (Clinical research ed.) · 2025Article
- SPIRIT 2025 statement: Updated guideline for protocols of randomised trials.PLoS medicine · 2025Article
- Surrogate Endpoints: CONSORT and SPIRIT Extensions.Journal of dental research · 2024Article
- Article
- Sample size in multistakeholder Delphi surveys: at what minimum sample size do replicability of results stabilize?Journal of clinical epidemiology · 2024Article
- Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration.BMJ (Clinical research ed.) · 2024Article
Corrections and comments
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Authors and funding
36 authors.
Anthony Muchai ManyaraMRC/CSO Social and Public Health Sciences Unit, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Philippa DaviesPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Derek StewartPatient author, UK.
Christopher J WeirEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Amber E YoungPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Jane BlazebyPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Nancy J ButcherChild Health Evaluative Sciences, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Sylwia BujkiewiczBiostatistics Research Group, Department of Population Health Sciences, University of Leicester, Leicester, UK.
An-Wen ChanWomen's College Research Institute, Toronto, ON, Canada.
Dalia DawoudScience, Evidence, and Analytics Directorate, Science Policy and Research Programme, National Institute for Health and Care Excellence, London, UK.
Martin OffringaChild Health Evaluative Sciences, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Mario OuwensAstraZeneca, Mölndal, Sweden.
Asbjørn HróbjartssonCentre for Evidence-Based Medicine Odense and Cochrane Denmark, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Alain AmstutzCLEAR Methods Centre, Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
Luca BertolacciniDepartment of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Vito Domenico BrunoIRCCS Galeazzi-Sant'Ambrogio Hospital, Department of Minimally Invasive Cardiac Surgery, Milan, Italy.
Declan DevaneUniversity of Galway, Galway, Ireland.
Christina D C M FariaDepartment of Physical Therapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Peter B GilbertFred Hutchinson Cancer Centre, Seattle, WA, USA.
Ray HarrisPatient author, UK.
Marissa LassereSt George Hospital and School of Population Health, University of New South Wales, Sydney, NSW, Australia.
Lucio MarinelliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genoa, Italy.
Sarah MarkhamPatient author, UK.
John H PowersGeorge Washington University School of Medicine, Washington, DC, USA.
Yousef RezaeiHeart Valve Disease Research Centre, Rajaie Cardiovascular Medical and Research Centre, Iran University of Medical Sciences, Tehran, Iran.
Laura RichertUniversity of Bordeaux, Centre d'Investigation Clinique-Epidémiologie Clinique 1401, Research in Clinical Epidemiology and in Public Health and European Clinical Trials Platform & Development/French Clinical Research Infrastructure Network, Institut National de la Santé et de la Recherche Médicale/Institut Bergonié/Centre Hospitalier Universitaire Bordeaux, Bordeaux, France.
Falk SchwendickeCharité Universitätsmedizin Berlin, Berlin, Germany.
Larisa G TereshchenkoDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Achilles ThomaMcMaster University, Hamilton, ON, Canada.
Alparslan TuranDepartment of Outcomes Research, Anaesthesiology Institute, Cleveland Clinic, OH, USA.
Andrew WorrallPatient author, UK.
Robin ChristensenSection for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen and Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.
Gary S CollinsUK EQUATOR Centre, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Joseph S RossDepartment of Health Policy and Management, Yale School of Public Health, New Haven, CT, USA.
Rod S TaylorMRC/CSO Social and Public Health Sciences Unit, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Oriana CianiCentre for Research on Health and Social Care Management, Bocconi University, Milan 20136, Italy oriana.ciani@unibocconi.it.ORCID 0000-0002-3607-0508
Funding
American Heart Association-American Stroke Association 23IPA1054947American Heart Association-American Stroke Association 23TPA1141088Cancer Research UK 27294
Abstract
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Indexed as
BiomarkersChecklistRandomized Controlled Trials as TopicClinical Trial Protocols as TopicHumansResearch DesignBiomarkers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.