Evidence map›Paper›PMID 38982272›Full record

ArticleScientific reports2024

Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease.

Bani Medegan Fagla, Jason York, Amy Christensen, Cielo Dela Rosa, Deebika Balu, Christian J Pike, Leon M Tai, Irina A Buhimschi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bani Medegan FaglaDepartment of Obstetrics Gynecology, University of Illinois at Chicago College of Medicine, 820 S. Wood Street, Chicago, IL, 60612, USA.
Jason York *Department of Anatomy and Cell Biology, University of Illinois at Chicago College of Medicine, Chicago, IL, 60612, USA.
Amy Christensen *Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Cielo Dela RosaDepartment of Obstetrics Gynecology, University of Illinois at Chicago College of Medicine, 820 S. Wood Street, Chicago, IL, 60612, USA.
Deebika BaluDepartment of Anatomy and Cell Biology, University of Illinois at Chicago College of Medicine, Chicago, IL, 60612, USA.
Christian J PikeDavis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Leon M TaiDepartment of Anatomy and Cell Biology, University of Illinois at Chicago College of Medicine, Chicago, IL, 60612, USA.
Irina A BuhimschiDepartment of Obstetrics Gynecology, University of Illinois at Chicago College of Medicine, 820 S. Wood Street, Chicago, IL, 60612, USA. irina@uic.edu.

Funding

Medical Scientist Training ProgramT32GM079086 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROSENBLATT, MARK I · 2007 to 2023
$6.9M
Deciphering molecular mechanisms that underlie brain endothelial cell dysfunction with APOE4R01AG061114 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Leon Maing Tai · 2019 to 2026
$4.7M
Dietary protection against APOE4 phenotypes in aging and Alzheimer'sR01AG084485 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHRISTIAN J PIKE · 2023 to 2026
$4.0M
Sex differences in the relationship between APOE and AD: Role of sexual differentiationRF1AG058068 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, LADU, MARY JO · 2017 to 2017
$3.8M
R01 Estrogen therapy and APOE4 risk in Alzheimer's tested in female EFAD miceR01AG057008 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LADU, MARY JO, THATCHER, GREGORY R. J · 2017 to 2020
$2.5M
Acquisition of a Q-Exactive HF Mass SpectrometerS10OD027016 · OD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COLOGNA, STEPHANIE M · 2019 to 2019
$600k
Potential ApoE Isoform-Specific Detrimental Effects of RXR Agonists in Alzheimer'R21AG044682 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LADU, MARY JO, THATCHER, GREGORY R. J · 2014 to 2015
$423k
NIA NIH HHS R01 AG057008NIA NIH HHS R01 AG061114NIA NIH HHS R01 AG084485NIA NIH HHS R21 AG044682NIA NIH HHS RF1 AG058068NIGMS NIH HHS T32 GM079086NIH HHS AG044682 (PI: LaDu)NIH HHS AG057008NIH HHS AG058068NIH HHS AG084485NIH HHS GM079086NIH HHS R01AG061114NIH HHS S10 OD027016
6 · The paper itself

Abstract

Apolipoprotein E (APOE) is a major cholesterol carrier responsible for lipid transport and injury repair in the brain. The human APOE gene (h-APOE) has 3 naturally occurring alleles: ε3, the common allele; ε4, which increases Alzheimer's disease (AD) risk up to 15-fold; and ε2, the rare allele which protects against AD. Although APOE4 has negative effects on neurocognition in old age, its persistence in the population suggests a survival advantage. We investigated the relationship between APOE genotypes and fertility in EFAD mice, a transgenic mouse model expressing h-APOE. We show that APOE4 transgenic mice had the highest level of reproductive performance, followed by APOE3 and APOE2. Intriguingly, APOE3 pregnancies had more fetal resorptions and reduced fetal weights relative to APOE4 pregnancies. In conclusion, APOE genotypes impact fertility and pregnancy outcomes in female mice, in concordance with findings in human populations. These mouse models may help elucidate how h-APOE4 promotes reproductive fitness at the cost of AD in later life.

Indexed as

Alzheimer DiseaseApolipoproteins EDisease Models, AnimalFertilityMice, TransgenicAllelesAnimalsApolipoprotein E3Apolipoprotein E4FemaleGenotypeHumansMicePolymorphism, GeneticPregnancyApoe protein, mouseApolipoprotein E3Apolipoprotein E4Apolipoproteins E

Identifiers

PMID38982272
PMCPMC11233746

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.