Evidence map›Paper›PMID 38982915›Full record

ArticleCurrent drug metabolism2024

Lingguizhugan Decoction Improved Obesity by Modulating the Gut Microbiota and its Metabolites in Mice.

Meiling Wang, Hairong Li, Chunmei Liu, Yuanyuan Zhang, Qian Wu, Yubin Yang

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Article in Current drug metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meiling WangTraditional Chinese Medicine Department, West China Second University Hospital, Sichuan University, Chengdu, China.
Hairong LiGuangdong Pharmaceutical University, Xiaoguwei Street, Panyu District, Guangzhou, China.
Chunmei LiuGuangdong Pharmaceutical University, Xiaoguwei Street, Panyu District, Guangzhou, China.
Yuanyuan ZhangGuangdong Pharmaceutical University, Xiaoguwei Street, Panyu District, Guangzhou, China.
Qian WuGuangdong Pharmaceutical University, Xiaoguwei Street, Panyu District, Guangzhou, China.
Yubin YangTraditional Chinese Medicine Department, West China Second University Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe global obese population is rapidly increasing, urgently requiring the development of effective and safe weight-loss medications. The classic Chinese medicine formulation Lingguizhugan Decoction has exerted a significant anti-obesity effect. However, the underlying mechanism is still unclear.

objectiveThis study aimed to explore the mechanism of LGZGD in the treatment of obesity based on the gut microbiota and its metabolites.

methodsThree different dosages of LGZGD were gavaged to ob/ob mice for 8 weeks. Body mass and visceral fat mass were evaluated. Additionally, the changes in gut microbiota, fecal and plasma metabolites in mice after LGZGD treatment were analyzed by metagenomics and non-targeted metabolomics.

resultsThe results demonstrated a significant anti-obesity effect of LGZGD treatment in ob/ob mice. Furthermore, the metagenomic analysis revealed that LGZGD reduced the ratio of

conclusionsThese findings suggested that LGZGD had therapeutic potential for obesity. The mechanism of LGZGD alleviating obesity was associated with improving dysbiosis of the gut microbiota. LDZGD affected gut microbiota-derived metabolites of EPA and MA and may act on energy metabolism pathways.

Indexed as

Drugs, Chinese HerbalGastrointestinal MicrobiomeObesityAnimalsAnti-Obesity AgentsFecesMaleMetabolomicsMiceMice, Inbred C57BLMice, ObesePlant ExtractsAnti-Obesity AgentsDrugs, Chinese Herballing-gui-zhu-gan decoctionPlant Extractsgut microbiotaLingguizhugan decoctionmetabolomics.metagenomicsobesityTraditional Chinese Medicine (TCM)

Identifiers

PMID38982915

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.