Evidence map›Paper›PMID 38983659›Full record

Trial reportWorld journal of methodology2024

Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?

Serafeim-Chrysovalantis Kotoulas, Kalliopi Domvri, Alexandros Tsantos, Ioanna Papagiouvanni, Anastasia Michailidou, Dionisios G Spyratos, Konstantinos Porpodis, Ioanna Grigoriou, Despina Papakosta, Athanasia Pataka

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of methodology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Serafeim-Chrysovalantis KotoulasIntensive Care Unit, Hippokration General Hospital, Thessaloniki 54642, Greece. akiskotoulas@hotmail.com.
Kalliopi DomvriPulmonary Department-Oncology Unit, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Alexandros Tsantos2nd Department of Internal Medicine, General Hospital of Thessaloniki ''Ippokration'', Thessaloniki 54642, Greece.
Ioanna PapagiouvanniFourth Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Thessaloniki, Greece.
Anastasia Michailidou2nd Propaedeutic Department of Internal Medicine, General Hospital of Thessaloniki "Ippokration", Thessaloniki 54642, Greece.
Dionisios G SpyratosDepartment of Pulmonary, Aristotle University of Thessaloniki, Thessaloniki 57001, Greece.
Konstantinos PorpodisDepartment of Pulmonary, Aristotle University of Thessaloniki, Thessaloniki 57001, Greece.
Ioanna GrigoriouRespiratory Failure Clinic, Papanikolaou General Hospital, Thessloniki 57001, Greece.
Despina PapakostaDepartment of Pulmonary, Aristotle University of Thessaloniki, Thessaloniki 57001, Greece.
Athanasia PatakaDepartment of Respiratory Medicine, Aristotle Univ Thessaloniki, Sch Med, G Papanikolaou Hosp, Resp Failure Unit, Aristotle University of Thessaloniki, Thessaloniki 57001, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElectronic cigarettes (ECs) have been promoted as alternatives to traditional cigarettes.

aimTo investigate ECs' effects on respiratory system, especially in patients with respiratory diseases.

methodsWe randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers. All were subjucted to pulmonary function tests (PFTs), impulse oscillometry (IOS), fraction exhaled Nitric Oxide (FeNO), exhaled breathe condensate (EBC) and biomarker measurements before and after vaping one nicotine-containing EC.

resultsThe increase in FeNO 30 minutes after EC, reflecting airway inflammation, significantly correlated with increase of residual volume (RV), total lung capacity, respiratory impedance at 5 Hz (Z5Hz) and respiratory resistance at 5 and 20 Hz (R5Hz and R20Hz). No significant correlations were found between EBC biomarkers' changes and respiratory mechanics.

conclusionThis is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.

Indexed as

Airway inflammationAsthmaElectronic cigaretteFeNOImpulse oscillometryLung function

Identifiers

PMID38983659
PMCPMC11229872

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.