ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Association of neuroticism with incident dementia, neuroimaging outcomes, and cognitive function.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Association of dietary copper intake with Alzheimer's disease, brain structure and cognitive function.The journal of nutrition, health & aging · 2026Article
- Association of family and friend relationship satisfaction with incident dementia: A prospective cohort study of 104,093 participants.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Functional gradient variations in different neuroticism levels and its correlation with cell type-specific transcriptional signatures.Social cognitive and affective neuroscience · 2026Article
- Association between neuroticism and brain-wide structural outcomes: Mediation by vascular and mental conditions.Psychological medicine · 2025Article
- Association of neuroticism with incident dementia and cognitive function: 26-year follow-up of EPIC-Norfolk study.Age and ageing · 2025Article
- Functional Impairment in Behavioral Variant Frontotemporal Dementia: Cognitive, Behavioral, Personality, and Brain Perfusion Contributions.Journal of personalized medicine · 2025Article
- Understanding Interactions Between Life Satisfaction and Genetic Predisposition on Risk of Alzheimer's Disease up to 14 Years Later: Findings From the UK Biobank.International journal of geriatric psychiatry · 2025Article
- Association of neuroticism with incident dementia, neuroimaging outcomes, and cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The relationship between personality traits and Alzheimer's disease: a narrative review.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionHigher neuroticism might be associated with dementia risk. Here we investigated modification by genetic predisposition to dementia, mediation by mental health and vascular conditions, neuroimaging outcomes, and cognitive function.
methodsCox proportional-hazards models were used to assess the association between neuroticism score and incident dementia over up to 15 years in 1,74,164 participants. Cross-sectional analyses on dementia-related neuroimaging outcomes and cognitive function were conducted in 39,459 dementia-free participants.
resultsHigher neuroticism was associated with an 11% higher risk of incident dementia, especially vascular dementia (15% higher risk), regardless of genetic predisposition to dementia. Mental and vascular conditions mediated the association of neuroticism with all-cause dementia and vascular dementia. Neuroticism was associated with higher cerebrovascular pathology, lower gray matter volume, and worse function across multiple cognitive domains. DISCUSSION: Neuroticism could represent a risk factor for dementia, and vascular and mental health might drive these associations. HIGHLIGHTS: Neuroticism was associated with an increased risk of incident all-cause dementia, particularly vascular dementia. Associations were not modified by genetic predisposition to dementia. Associations were largely mediated by mental and vascular conditions. Neuroticism was associated with increased cerebrovascular pathology and lower gray matter volume. Neuroticism was associated with worse function across multiple cognitive domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.