Evidence map›Paper›PMID 38984683›Full record

ReviewExpert opinion on drug metabolism & toxicology2024

Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety.

Jyotshna Kanungo, Barbara C Sorkin, Julie Krzykwa, Constance A Mitchell, Michelle Embry, Peter Spencer, G Jean Harry, Jason Cannon, Fang Liu, Christopher A McPherson and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on drug metabolism & toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jyotshna KanungoDivision of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.
Barbara C SorkinOffice of Dietary Supplements, Division of Program Coordination, Planning, and Strategic Initiatives, U.S. National Institutes of Health, Bethesda, MD, USA.
Julie KrzykwaHealth and Environmental Sciences Institute, Washington, DC, USA.
Constance A MitchellHealth and Environmental Sciences Institute, Washington, DC, USA.
Michelle EmbryHealth and Environmental Sciences Institute, Washington, DC, USA.
Peter SpencerDepartment of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
G Jean HarryMechanistic Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA.
Jason CannonPurdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, USA.
Fang LiuDivision of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.
Christopher A McPhersonMechanistic Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA.
Stefan GafnerAmerican Botanical Council, Austin, TX, USA.
Remco H S WesterinkDivision of Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Funding

Toxicological Assessments for the National Toxicology ProgramZIAES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2016 to 2019
$31.9M
Developmental Neurotoxicity Health Effects Innovation Research ProgramZIAES103387 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MCPHERSON, CHRISTOPHER ANTHONY · 2022 to 2025
$5.2M
Environment Effects and Development of Neuron and GliaZ01ES021164 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 1997 to 2008
$409k
CELLULAR INDICATORS OF NEURONAL INSULTZ01ES021154 · NIEHS · ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 1992 to 2004
–
Intramural NIH HHS Z01 ES021154Intramural NIH HHS Z01 ES021164Intramural NIH HHS Z99 ES999999Intramural NIH HHS ZIA ES103316
6 · The paper itself

Abstract

areas coveredThis paper outlines the selection of NAMs, including in vitro assays using primary rat cortical neurons, zebrafish embryos, and EXPERT OPINION: The complexity of botanicals necessitates the use of multiple NAMs for effective neurotoxicity screening. This paper discusses the evaluation of methodologies to develop a robust framework for evaluating botanical safety, including complex neuronal models and key neurodevelopmental process assays. It aims to establish a comprehensive screening framework.

Indexed as

Caenorhabditis elegansNeuronsNeurotoxicity SyndromesToxicity TestsZebrafishAnimalsDrug Evaluation, PreclinicalEmbryo, NonmammalianHumansPlant ExtractsPlant PreparationsRatsPlant ExtractsPlant PreparationsBotanicalcomplex mixturesin vitroNAMneurotoxicityscreeningUVCB

Identifiers

PMID38984683
PMCPMC11542175

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.