Observational studyNutrition & diabetes2024
A mixed meal tolerance test predicts onset of type 2 diabetes in Southwestern Indigenous adults.
Observational study in Nutrition & diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Studies of Diabetes Mellitus and Its Complications in the Gila River Indian Community
Cross-Sectional and Longitudinal Studies of 'Pre-Diabetes'
Who cites it
3 citing papers in PubMed.
- Dependency of Glucose Homeostasis on Pancreatic Enzymes with Special Reference to Amylase; Study on Healthy and Exocrine Pancreatic Insufficient Pigs.Biomolecules · 2026Article
- Two-dimensional Health State Map to define metabolic health using separated static and dynamic homeostasis features: a proof-of-concept study.National science review · 2025Article
- The need for a prognostic biomarker and challenge test for phenotypic flexibility.Nutrition & diabetes · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
BACKGROUND/
objectiveTo identify predictors of incident type 2 diabetes using a mixed meal tolerance test (MMTT).
methodsAdult Indigenous Americans without diabetes (n = 501) from a longitudinal cohort underwent at baseline a 4-h MMTT, measures of body composition, an oral glucose tolerance test, an intravenous glucose tolerance test for acute insulin response (AIR), and a hyperinsulinemic-euglycemic clamp for insulin action (M). Plasma glucose responses from the MMTT were quantified by the total and incremental area under the curve (AUC/iAUC).
resultsAt follow-up (median time 9.6 [inter-quartile range: 5.6-13.5] years), 169 participants were diagnosed with diabetes. Unadjusted Cox proportional hazards models, glucose AUC
conclusionsGlucose responses to a mixed meal predicted the development of type 2 diabetes. This indicates that a mixed nutritional challenge provides important information on disease risk. CLINICAL TRIAL REGISTRY: ClinicalTrials.gov identifier : NCT00340132, NCT00339482.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.