Evidence map›Paper›PMID 38988495›Full record

ArticleMedComm2024

Chromothripsis is a novel biomarker for prognosis and differentiation diagnosis of pancreatic neuroendocrine neoplasms.

Ming-Yi Zhang, Du He, Yi Zhang, Ke Cheng, Hong-Shuai Li, Yu-Wen Zhou, Qiong-Xian Long, Rui-Zhi Liu, Ji-Yan Liu

Abstract read
In one paragraph

Article in MedComm, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Chromothripsis.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ming-Yi ZhangDepartment of Biotherapy, West China Hospital Sichuan University Chengdu Sichuan China.
Du HeDepartment of Pathology, West China Hospital Sichuan University Chengdu Sichuan China.
Yi ZhangCenter of Life Sciences Peking University Beijing China.
Ke ChengDepartment of Biotherapy, West China Hospital Sichuan University Chengdu Sichuan China.
Hong-Shuai LiDepartment of Biotherapy, West China Hospital Sichuan University Chengdu Sichuan China.
Yu-Wen ZhouDepartment of Biotherapy, West China Hospital Sichuan University Chengdu Sichuan China.
Qiong-Xian LongDepartment of Pathology, Nan Chong Central Hospital the Second Affiliated Hospital of North Sichuan Medical College Nanchong Sichuan China.
Rui-Zhi LiuSchool of Medical and Life Sciences Chengdu University of Traditional Chinese Medicine Chengdu Sichuan China.
Ji-Yan LiuDepartment of Biotherapy, West China Hospital Sichuan University Chengdu Sichuan China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to identify the role of chromothripsis as a novel biomarker in the prognosis and differentiation diagnosis of pancreatic neuroendocrine neoplasms (pNENs). We conducted next-generation gene sequencing in a cohort of 30 patients with high-grade (G3) pNENs. As a reference, a similar analysis was also performed on 25 patients with low-grade (G1/G2) pancreatic neuroendocrine tumors (pNETs). Chromothripsis and its relationship with clinicopathological features and prognosis were investigated. The results showed that DNA damage response and repair gene alteration and

Indexed as

chromothripsisDDR genedifferentiation diagnosispancreatic neuroendocrine neoplasmsprognosisTP53

Identifiers

PMID38988495
PMCPMC11234462

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.