Evidence map›Paper›PMID 38989460›Full record

ArticleiScience2024

AutoCancer as an automated multimodal framework for early cancer detection.

Linjing Liu, Ying Xiong, Zetian Zheng, Lei Huang, Jiangning Song, Qiuzhen Lin, Buzhou Tang, Ka-Chun Wong

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Linjing LiuDepartment of Computer Science, City University of Hong Kong, Kowloon Tong, Hong Kong SAR.
Ying XiongDepartment of Computer Science, Harbin Institute of Technology (Shenzhen), Shenzhen, China.
Zetian ZhengDepartment of Computer Science, City University of Hong Kong, Kowloon Tong, Hong Kong SAR.
Lei HuangDepartment of Computer Science, City University of Hong Kong, Kowloon Tong, Hong Kong SAR.
Jiangning SongMonash Biomedicine Discovery Institute and Monash Data Futures Institute, Monash University, Melbourne, VIC 3800, Australia.
Qiuzhen LinCollege of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China.
Buzhou TangDepartment of Computer Science, Harbin Institute of Technology (Shenzhen), Shenzhen, China.
Ka-Chun WongDepartment of Computer Science, City University of Hong Kong, Kowloon Tong, Hong Kong SAR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current studies in early cancer detection based on liquid biopsy data often rely on off-the-shelf models and face challenges with heterogeneous data, as well as manually designed data preprocessing pipelines with different parameter settings. To address those challenges, we present AutoCancer, an automated, multimodal, and interpretable transformer-based framework. This framework integrates feature selection, neural architecture search, and hyperparameter optimization into a unified optimization problem with Bayesian optimization. Comprehensive experiments demonstrate that AutoCancer achieves accurate performance in specific cancer types and pan-cancer analysis, outperforming existing methods across three cohorts. We further demonstrated the interpretability of AutoCancer by identifying key gene mutations associated with non-small cell lung cancer to pinpoint crucial factors at different stages and subtypes. The robustness of AutoCancer, coupled with its strong interpretability, underscores its potential for clinical applications in early cancer detection.

Indexed as

CancerCancer systems biologyComputing methodologyHealth sciencesMachine learning

Identifiers

PMID38989460
PMCPMC11233972

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.