Evidence map›Paper›PMID 38990486›Full record

ArticleVirus genes2024

Comparative analysis of two novel complete genomes of myxoma virus vaccine strains.

Sofya Volodina, Ilya Titov, Sergey Zhivoderov, Sergey Yurkov, Alexander Malogolovkin

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Virus genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sofya VolodinaMolecular Virology Laboratory, First Moscow State Medical University (Sechenov University), Trubetskaya 8, 119048, Moscow, Russia.
Ilya TitovFederal Research Center for Virology and Microbiology, Bakoulova Street, B.1, 601125, Volginskiy, Russia.
Sergey ZhivoderovFederal Research Center for Virology and Microbiology, Bakoulova Street, B.1, 601125, Volginskiy, Russia.
Sergey YurkovFederal Research Center for Virology and Microbiology, Bakoulova Street, B.1, 601125, Volginskiy, Russia.
Alexander MalogolovkinMolecular Virology Laboratory, First Moscow State Medical University (Sechenov University), Trubetskaya 8, 119048, Moscow, Russia. Malogolovkin_a_s@staff.sechenov.ru.ORCID http://orcid.org/0000-0003-1352-1780

Funding

Ministry of Science and Higher Education of the Russian Federation Priority-2030
6 · The paper itself

Abstract

Myxoma virus (MYXV) is a double-stranded DNA-containing virus of the family Poxviridae, genus Leporipoxvirus. MYXV is an important model virus for evolutionary and immunological research and a promising oncolytic. In this study, we sequenced and analyzed two complete genomes of MYXV virus vaccine strains B-82 and Rabbivac-B, which are widely used for vaccine production in Russia. Here, we first show that MYXV vaccine strains B-82 and Rabbivac-B share a common origin with the American recombinant MYXV MAV vaccine strain. In addition, our data suggest that the MYXV B-82 and Rabbivac-B strains contain a number of genes at the 5' and 3' ends that are identical to the virulent MYXV Lausanne strain. Several unique genetic signatures were identified in the M013L, M017L, M023, and M121R genes, helping to achieve high genetic resolution between vaccine strains. Overall, these findings highlight the evolutionary flexibility of certain genes in the MYXV genome and provide insights into the molecular epidemiology of the virus and subsequent vaccine development.

Indexed as

Genome, ViralMyxoma virusPhylogenyViral VaccinesAnimalsEvolution, MolecularRussiaViral VaccinesMyxoma virusPoxvirusRabbitsVaccineWhole-genome sequencing

Identifiers

PMID38990486

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.