Evidence mapPaperPMID 38990855Full record

ArticleJournal of medicinal chemistry2024

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB

Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi and 11 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Chemical Probes for Investigating the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Leonard MachLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Anahid OmranLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Jara BoumaDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University and Oncode Institute, 2333 CC Leiden, The Netherlands.ORCID 0000-0002-6572-6158
Silke RadetzkiLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
David A SykesDivision of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham, NG7 2UH Nottingham, U.K.
Wolfgang GubaRoche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.ORCID 0000-0002-3285-5957
Xiaoting LiiHuman Institute, ShanghaiTech University, 201210 Shanghai, China.
Calvin HöffelmeyerLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Axel HentschLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Thais GazziLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Yelena MostinskiLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Malgorzata Wasinska-KalwaLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Fabio de MolnierIRR Chemistry Hub and Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, EH16 4UU Edinburgh, U.K.
Cas van der HorstDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University and Oncode Institute, 2333 CC Leiden, The Netherlands.
Jens Peter von KriesLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Marc VendrellIRR Chemistry Hub and Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, EH16 4UU Edinburgh, U.K.
Tian HuaiHuman Institute, ShanghaiTech University, 201210 Shanghai, China.
Dmitry B VeprintsevDivision of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham, NG7 2UH Nottingham, U.K.ORCID 0000-0002-3583-5409
Laura H HeitmanDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University and Oncode Institute, 2333 CC Leiden, The Netherlands.ORCID 0000-0002-1381-8464
Uwe GretherRoche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.ORCID 0000-0002-3164-9270
Marc NazareLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0002-1602-2330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cannabinoid receptor type 1 (CB

Indexed as

Fluorescent DyesReceptor, Cannabinoid, CB1Cyclic AMPHEK293 CellsHumansLigandsMolecular Docking SimulationPyrrolesStructure-Activity RelationshipCyclic AMPFluorescent DyesLigandsPyrrolesReceptor, Cannabinoid, CB1

Identifiers

PMID38990855
PMCPMC11284800

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.