Evidence map›Paper›PMID 38991492›Full record

ArticleJournal of diabetes and its complications2024

Muscle mitochondrial function is impaired in adults with type 1 diabetes.

Daniel Gottlieb, Layla A Abushamat, Kristen J Nadeau, Judith G Regensteiner, Jane E B Reusch, Kalie L Tommerdahl, John Rice, Leslie A Knaub, Cynthia M F Monaco, Thomas J Hawke and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes and its complications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daniel GottliebNYU Langone Department of Pediatrics, New York City, NY, USA.
Layla A AbushamatDepartment of Medicine, Baylor College of Medicine, 1 Baylor Plaza, BCM 285, Houston TX77030, USA; Department of Medicine, Division of Endocrinology, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., 7103, Research 1 South, Aurora, CO 80045, USA.
Kristen J NadeauDepartment of Pediatrics, Section of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Judith G RegensteinerLudeman Family Center for Women's Health Research, 12348 East Montview Boulevard, Mail Stop C-263, Aurora, CO 80045, USA; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, 12631 East 17th Avenue, B130, Aurora, CO 80045, USA.
Jane E B ReuschLudeman Family Center for Women's Health Research, 12348 East Montview Boulevard, Mail Stop C-263, Aurora, CO 80045, USA; Department of Medicine, Division of Endocrinology, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., 7103, Research 1 South, Aurora, CO 80045, USA; Department of Medicine, Division of Endocrinology, Rocky Mountain Regional Veterans Affairs Medical Center, 1700 N Wheeling St, Aurora, CO 80045, USA.
Kalie L TommerdahlDepartment of Pediatrics, Section of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Ludeman Family Center for Women's Health Research, 12348 East Montview Boulevard, Mail Stop C-263, Aurora, CO 80045, USA; Barbara Davis Center for Diabetes, 1775 Aurora Ct # A140, Aurora, CO 80045, USA.
John RiceDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, 13001 East 17th Place, 3rd Floor, Mail Stop B119, Aurora, CO 80045, USA.
Leslie A KnaubDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, 12631 East 17th Avenue, B130, Aurora, CO 80045, USA; Department of Medicine, Division of Endocrinology, Rocky Mountain Regional Veterans Affairs Medical Center, 1700 N Wheeling St, Aurora, CO 80045, USA.
Cynthia M F MonacoDepartment of Pathology & Molecular Medicine, McMaster University, Health Sciences Centre, Room 2N15, 1200 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Thomas J HawkeDepartment of Pathology & Molecular Medicine, McMaster University, Health Sciences Centre, Room 2N15, 1200 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
Christopher G R PerrySchool of Kinesiology & Health Sciences, Muscle Health Research Centre, York University, Norman Bethune College, 170 Campus Walk Room 341, Toronto, ON M3J 1P3, Canada.
Melanie G CreeDepartment of Pediatrics, Section of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Irene E SchauerLudeman Family Center for Women's Health Research, 12348 East Montview Boulevard, Mail Stop C-263, Aurora, CO 80045, USA; Department of Medicine, Division of Endocrinology, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., 7103, Research 1 South, Aurora, CO 80045, USA; Department of Medicine, Division of Endocrinology, Rocky Mountain Regional Veterans Affairs Medical Center, 1700 N Wheeling St, Aurora, CO 80045, USA. Electronic address: Irene.Schauer@CUAnschutz.edu.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
ZOPOLRESTAT PHARMACOKINETICS IN DIABETICS WITH VARYING RENAL FUNCTIONM01RR000051 · NCRR · UNIVERSITY OF COLORADO DENVER · PI KRUGMAN, RICHARD D. · 1985 to 2008
$52.6M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
VRAC and Rho in pulmonary EC proliferationP01HL014985 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STENMARK, KURT R. · 1985 to 2019
$35.1M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Paul S. Maclean · 1995 to 2026
$32.6M
ZORVIRAX ORAL SUSPENSION FOR SEVERE CHILDHOOD HERPES VIRUS INFECTIONSM01RR000069 · NCRR · UNIVERSITY OF COLORADO DENVER · PI KRUGMAN, RICHARD D. · 1985 to 2008
$22.1M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
UCHSC: Building Interdisciplinary Research Careers in Women's HealthK12HD057022 · NICHD · UNIVERSITY OF COLORADO DENVER · PI REGENSTEINER, JUDITH G., SANTORO, NANETTE F. · 2007 to 2023
$8.5M
TRAINING IN RENAL &ELECTROLYTE DISEASE &HYPERTENSIONT32DK007135 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JOHNSON, RICHARD JOSEPH, KENDRICK, JESSICA B · 1986 to 2024
$5.3M
Training Program in Diabetes ResearchT32DK063687 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Andrea Steck · 2002 to 2026
$5.2M
Role of Microvascular insulin resistance and cardiorespiratory fitness in diabetesR01DK124344 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ZHENQI LIU, JUDITH G. REGENSTEINER · 2021 to 2026
$3.5M
BLRD VA I01 BX002046BLRD VA IK2 BX004533CSRD VA I01 CX001532NCATS NIH HHS UL1 TR001082NCATS NIH HHS UL1 TR002535NCRR NIH HHS M01 RR000051NCRR NIH HHS M01 RR000069NCRR NIH HHS TL1 RR025778NCRR NIH HHS UL1 RR025780NHLBI NIH HHS K23 HL159292NHLBI NIH HHS K24 HL145076NHLBI NIH HHS L40 HL159798NHLBI NIH HHS P01 HL014985NICHD NIH HHS K12 HD057022NIDDK NIH HHS K23 DK091553NIDDK NIH HHS K23 DK107871NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK124344NIDDK NIH HHS R56 DK088971NIDDK NIH HHS T32 DK007135NIDDK NIH HHS T32 DK063687NIH HHS S10 OD018435
6 · The paper itself

Abstract

aimsType 1 diabetes has been associated with mitochondrial dysfunction. However, the mechanism of this dysfunction in adults remains unclear.

methodsA secondary analysis was conducted using data from several clinical trials measuring in-vivo and ex-vivo mitochondrial function in adults with type 1 diabetes (n = 34, age 38.8 ± 14.6 years) and similarly aged controls (n = 59, age 44.6 ± 13.9 years). In-vivo mitochondrial function was assessed before, during, and after isometric exercise with

resultsIn-vivo data showed higher rates of anaerobic glycolysis (p = 0.013), and a lower maximal mitochondrial oxidative capacity (p = 0.012) and mitochondrial efficiency (p = 0.024) in adults with type 1 diabetes. After adjustment for age and percent body fat maximal mitochondrial capacity (p = 0.014) continued to be lower and anaerobic glycolysis higher (p = 0.040) in adults with type 1 diabetes. Ex-vivo data did not demonstrate significant differences between the two groups.

conclusionsThe in-vivo analysis demonstrates that adults with type 1 diabetes have mitochondrial dysfunction. This builds on previous research showing in-vivo mitochondrial dysfunction in youths with type 1 diabetes and suggests that defects in substrate or oxygen delivery may play a role in in-vivo dysfunction.

Indexed as

Diabetes Mellitus, Type 1Mitochondria, MuscleAdultCase-Control StudiesExerciseFemaleGlycolysisHumansMagnetic Resonance SpectroscopyMaleMiddle AgedMitochondrial DiseasesMuscle, SkeletalYoung Adult(31)phosphorous magnetic resonance spectroscopyHigh-resolution respirometryInsulin resistanceMitochondrial functionMuscle

Identifiers

PMID38991492
PMCPMC11288176

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.