ArticleEMBO reports2024
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF
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Article in EMBO reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Nanomaterial-driven spatiotemporal autophagy modulation: The dual-edged sword in precision cancer therapy.Acta pharmaceutica Sinica. B · 2026Review
- Mechanisms and Therapeutic Potential of Targeting Mitophagy in Neurodegenerative Diseases.Molecular neurobiology · 2026Review
- Regulation and roles of mammalian mitophagy.Nature reviews. Molecular cell biology · 2026Review
- Activation of AMPK as a therapeutic strategy for FBXL4-related mitochondrial DNA depletion syndrome.EMBO molecular medicine · 2026Article
- Sustained loss ofbioRxiv : the preprint server for biology · 2026Article
- Molecular diversity of mitochondrial autophagy receptors: context-dependent effects in human health and disease.Cell death discovery · 2026Review
- The PPTC7/BNIP3/NIX axis induces cGAS/STING-mediated senescence and augments CAR-T efficacy by repressing tumor-intrinsic mitophagy.Journal of experimental & clinical cancer research : CR · 2026Article
- Function and regulation of the mitochondrial stress response.Nature structural & molecular biology · 2026Review
- Recessive PPTC7 deficiency triggers excessive mitophagy to cause a severe inborn error of metabolism with hypomyelinating leukodystrophy.Research square · 2026Article
- Mitophagy in the pathogenesis and management of disease.Cell research · 2026Review
- Mechanism of autophagy initiation by transmembrane selective autophagy receptors.The EMBO journal · 2025Review
- F-box proteins in cancer: from cancer cells to the tumor microenvironment.Cell communication and signaling : CCS · 2025Review
- Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery.Nature cell biology · 2025Article
- Stressful situations: Molecular insights on mitochondrial quality control pathways.The Journal of biological chemistry · 2025Review
- Sex and region-specific disruption of autophagy and mitophagy in Alzheimer's disease: linking cellular dysfunction to cognitive decline.Cell death discovery · 2025Article
- A new perspective on protecting the blood-retinal barrier against injury in diabetic retinopathy: mitophagy.Frontiers in endocrinology · 2025Review
- Coordinating BNIP3/NIX-mediated mitophagy in space and time.Biochemical Society transactions · 2024Review
- Dual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX.Life science alliance · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Giang Thanh Nguyen-Dien *Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0002-3136-0485
Brendan Townsend *Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0003-2839-8981
Prajakta Gosavi Kulkarni *Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0002-0960-8237
Keri-Lyn Kozul *Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0001-5162-4807
Soo Siang OoiFaculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.
Denaye N EldershawThe University of Queensland, Institute for Molecular Bioscience, Brisbane, QLD, 4072, Australia.ORCID 0009-0000-8032-0378
Saroja WeeratungaThe University of Queensland, Institute for Molecular Bioscience, Brisbane, QLD, 4072, Australia.ORCID 0009-0009-8417-7420
Meihan LiuThe University of Queensland, Institute for Molecular Bioscience, Brisbane, QLD, 4072, Australia.ORCID 0009-0006-7463-4497
Mathew Jk JonesThe University of Queensland Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, 4102, Australia.ORCID 0000-0003-2714-8411
S Sean MillardFaculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0001-8573-4625
Dominic Ch NgFaculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.
Michele PaganoDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, 10016, USA.ORCID 0000-0003-3210-2442
Alexis Bonfim-MeloThe University of Queensland Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, 4102, Australia.
Tobias SchneiderWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0009-0009-6076-9202
David KomanderWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0002-8092-4320
Michael LazarouDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3068, Australia.ORCID 0000-0003-2150-5545
Brett M CollinsThe University of Queensland, Institute for Molecular Bioscience, Brisbane, QLD, 4072, Australia. b.collins@imb.uq.edu.au.ORCID 0000-0002-6070-3774
Julia K PaganFaculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia. j.pagan@uq.edu.au.ORCID 0000-0002-7079-6388
Funding
Regulation of the cell proliferation by CRL ubiquitin ligases-diversity supplementR35GM136250 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MICHELE PAGANO · 2020 to 2026
$2.7MDepartment of Education and Training | Australian Research Council (ARC) FT180100172DHAC | National Health and Medical Research Council (NHMRC) APP1183915 and APP1136021DHAC | National Health and Medical Research Council (NHMRC) APP2016410NIGMS NIH HHS R35 GM136250
Abstract
Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of functional mitochondria. The SCF
Indexed as
F-Box ProteinsMembrane ProteinsMitochondrial ProteinsMitophagyProteolysisProto-Oncogene ProteinsAnimalsHEK293 CellsHeLa CellsHumansMitochondriaMitochondrial MembranesPhosphoprotein PhosphatasesProtein BindingProtein Phosphatase 2CSKP Cullin F-Box Protein LigasesBNIP3L protein, humanBNIP3 protein, humanF-Box ProteinsFbxL4 protein, humanMembrane ProteinsMitochondrial ProteinsPhosphoprotein PhosphatasesPPTC7 protein, humanProtein Phosphatase 2CProto-Oncogene ProteinsSKP Cullin F-Box Protein LigasesTumor Suppressor ProteinsUbiquitin-Protein LigasesBNIP3FBXL4MitophagyNIXPPTC7
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.