Evidence map›Paper›PMID 38993377›Full record

ArticleGMS hygiene and infection control2024

Can toothbrushing reduce the intraoral viral load of SARS-CoV-2? A pilot study with a dentifrice containing an antimicrobial phthalocyanine derivative.

Marcelo Lupion Poleti, Danielle Gregório, Alisson Gabriel Idelfonso Bistaffa, Fabiano Vieira Vilhena, Andréa Name Colado Simão, Mayara Tiemi Enokida Mori, Nicole Perugini Stadtlober, Marcell Alysson Batisti Lozovoy, Paulo Sérgio da Silva Santos, Berenice Tomoko Tatibana and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GMS hygiene and infection control, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marcelo Lupion PoletiOral Health, Federal Institute of Paraná - IFPR, Londrina, Brazil.
Danielle GregórioPostgraduate Program in Dentistry, School of Dentistry, University of North Paraná - UNOPAR/UNIDERP, Londrina, Brazil.
Alisson Gabriel Idelfonso BistaffaPostgraduate Program in Dentistry, School of Dentistry, University of North Paraná - UNOPAR/UNIDERP, Londrina, Brazil.
Fabiano Vieira VilhenaTRIALS - Oral Health & Technologies, Bauru, Brazil.
Andréa Name Colado SimãoResearch Laboratory in Applied Immunology, Department of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Londrina, Brazil.
Mayara Tiemi Enokida MoriResearch Laboratory in Applied Immunology, Department of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Londrina, Brazil.
Nicole Perugini StadtloberResearch Laboratory in Applied Immunology, Department of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Londrina, Brazil.
Marcell Alysson Batisti LozovoyResearch Laboratory in Applied Immunology, Department of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Londrina, Brazil.
Paulo Sérgio da Silva SantosDepartment of Surgery, Stomatology, Pathology, and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
Berenice Tomoko TatibanaOral Health, Federal Institute of Paraná - IFPR, Londrina, Brazil.
Thais Maria Freire FernandesPostgraduate Program in Dentistry, School of Dentistry, University of North Paraná - UNOPAR/UNIDERP, Londrina, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to assess whether toothbrushing with a dentifrice containing an antimicrobial phthalocyanine derivative (APD) can reduce the intraoral viral load of SARS-CoV-2. Twenty COVID-19-positive dentate patients aged ≥18 years were selected instructed to brush their teeth for 2 min with a dentifrice containing APD. Self-collected samples of unstimulated saliva were carried out three times: T0 (baseline), T5 (5 min after toothbrushing), and T30 (30 min after toothbrushing). The analysis of viral RNA was performed by RT-qPCR for detection of three viral genes (ORF1ab, N and S genes). Results were statistically tested using Friedman's test and pairwise comparison with Bonferroni corrections, with a significance level of 5%. There was an increase in the cycle threshold (Ct) value from T0 to T5 in 13 patients (72.2%), and from T0 to T30 in 14 patients (77.8%). In two patients (11.1%) no SARS-CoV-2 was detected at T5 and five patients (27.8%) at T30. The Ct values were statistically significantly higher (p=0.020) at T30 in comparison to T0 and T5. This pilot study suggests that toothbrushing with a dentifrice containing APD could reduce the SARS-CoV-2 viral load in the oral cavity. However, further studies are needed to confirm this possible beneficial effect against SARS-CoV-2.

Identifiers

PMID38993377
PMCPMC11238404

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.