Evidence map›Paper›PMID 38993571›Full record

ArticleInternational journal of biological sciences2024

Molecular Interaction of Soluble Klotho with FGF23 in the Pathobiology of Aortic Valve Lesions Induced by Chronic Kidney Disease.

Erlinda The, Yufeng Zhai, Qingzhou Yao, Lihua Ao, David A Fullerton, Xianzhong Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. [Potential of early diagnosis and targeted therapy for Klotho protein in chronic kidney disease].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erlinda TheDepartments of Surgery and Medicine, University of Colorado Denver, Aurora, CO 80045, USA.
Yufeng ZhaiDepartments of Surgery and Medicine, University of Colorado Denver, Aurora, CO 80045, USA.
Qingzhou YaoDepartments of Surgery and Medicine, University of Colorado Denver, Aurora, CO 80045, USA.
Lihua AoDepartments of Surgery and Medicine, University of Colorado Denver, Aurora, CO 80045, USA.
David A FullertonDepartments of Surgery and Medicine, University of Colorado Denver, Aurora, CO 80045, USA.
Xianzhong MengDepartments of Surgery and Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

Funding

Suppression of AVIC inflammosteogenesis for prevention of CAVD progressionR01HL121776 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MENG, XIANZHONG · 2015 to 2023
$3.6M
NHLBI NIH HHS R01 HL121776
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is linked to greater prevalence and rapid progression of calcific aortic valve disease (CAVD) characterized by valvular leaflet fibrosis and calcification. Fibroblast growth factor 23 (FGF23) level is elevated, and anti-aging protein Klotho is reduced in CKD patients. However, the roles of FGF23 and Klotho in the mechanism of aortic valve fibrosis and calcification remain unclear. We hypothesized that FGF23 mediates CKD-induced CAVD by enhancing aortic valve interstitial cell (AVIC) fibrosis and calcification, while soluble Klotho inhibits FGF23 effect.

Indexed as

Aortic ValveFibroblast Growth Factor-23Fibroblast Growth FactorsGlucuronidaseKlotho ProteinsRenal Insufficiency, ChronicAnimalsAortic Valve StenosisCalcinosisDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLSignal TransductionFGF23 protein, humanFgf23 protein, mouseFibroblast Growth Factor-23Fibroblast Growth FactorsGlucuronidaseKlotho Proteinscalcific aortic valve diseaseChronic kidney diseasefibroblast growth factor 23KlothoYAP

Identifiers

PMID38993571
PMCPMC11234222

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.