Evidence map›Paper›PMID 38995814›Full record

ArticleG3 (Bethesda, Md.)2024

Genome assembly of Hibiscus sabdariffa L. provides insights into metabolisms of medicinal natural products.

Taein Kim, Jeong Hun Lee, Hyo Hyun Seo, Sang Hyun Moh, Sung Soo Choi, Jun Kim, Sang-Gyu Kim

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Taein KimDepartment of Biological Sciences, KAIST, Yuseong-gu, 34141 Daejeon, Republic of Korea.
Jeong Hun LeePlant Cell Research Institute, BIO-FD&C Co., Ltd, Yeonsu-gu, 21990 Incheon, Republic of Korea.
Hyo Hyun SeoPlant Cell Research Institute, BIO-FD&C Co., Ltd, Yeonsu-gu, 21990 Incheon, Republic of Korea.
Sang Hyun MohPlant Cell Research Institute, BIO-FD&C Co., Ltd, Yeonsu-gu, 21990 Incheon, Republic of Korea.
Sung Soo ChoiDaesang Holdings, Jung-gu, 04513 Seoul, Republic of Korea.
Jun KimDepartment of Convergent Bioscience and Informatics, College of Bioscience and Biotechnology, Chungnam National University, Yuseong-gu, 34134 Daejeon, Republic of Korea.
Sang-Gyu KimDepartment of Biological Sciences, KAIST, Yuseong-gu, 34141 Daejeon, Republic of Korea.

Funding

Daesang HoldingsNational Research Foundation of Korea 2018R1A5A7025409
6 · The paper itself

Abstract

Hibiscus sabdariffa L. is a widely cultivated herbaceous plant with diverse applications in food, tea, fiber, and medicine. In this study, we present a high-quality genome assembly of H. sabdariffa using more than 33 Gb of high-fidelity (HiFi) long-read sequencing data, corresponding to ∼20× depth of the genome. We obtained 3 genome assemblies of H. sabdariffa: 1 primary and 2 partially haplotype-resolved genome assemblies. These genome assemblies exhibit N50 contig lengths of 26.25, 11.96, and 14.50 Mb, with genome coverage of 141.3, 86.0, and 88.6%, respectively. We also utilized 26 Gb of total RNA sequencing data to predict 154k, 79k, and 87k genes in the respective assemblies. The completeness of the primary genome assembly and its predicted genes was confirmed by the benchmarking universal single-copy ortholog analysis with a completeness rate of 99.3%. Based on our high-quality genomic resources, we constructed genetic networks for phenylpropanoid and flavonoid metabolism and identified candidate biosynthetic genes, which are responsible for producing key intermediates of roselle-specific medicinal natural products. Our comprehensive genomic and functional analysis opens avenues for further exploration and application of valuable natural products in H. sabdariffa.

Indexed as

Biological ProductsGenome, PlantHibiscusGenomicsMolecular Sequence AnnotationPlants, MedicinalBiological Productsbiosynthetic pathwayHibiscus sabdariffaHiFi sequencingnatural product

Identifiers

PMID38995814
PMCPMC11304979

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.