ArticleScience advances2024
27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior.
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Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
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Who cites it
8 citing papers in PubMed.
- Serotonin neurons in the dorsal raphe control food-craving-like behavior during pregnancy in mice.Nature neuroscience · 2026Article
- Article
- 27-Hydroxycholesterol in cancer development and drug resistance.Journal of enzyme inhibition and medicinal chemistry · 2025Review
- Mechanisms of high-density lipoprotein in regulating blood-brain barrier function: insights and implications.Fluids and barriers of the CNS · 2025Review
- The Crunchometer: A Low-Cost, Open-Source Acoustic Analysis of Feeding Microstructure.bioRxiv : the preprint server for biology · 2025Article
- Hypothalamic Estrogen Receptor α Is Essential for Female Marmoset Sexual Behavior Without Protecting From Obesity.Journal of the Endocrine Society · 2025Article
- Effects of voluntary wheel running on appetite-regulating peptides and neuroinflammation in the hypothalamus of ovariectomized middle-aged mice.Frontiers in molecular neuroscience · 2025Article
- The interaction of BDNF with estrogen in the development of hypertension and obesity, particularly during menopause.Frontiers in endocrinology · 2024Review
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Authors and funding
24 authors.
Hui YeSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 639798, Singapore.ORCID 0000-0002-8473-0603
Xiaohua YangDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Bing FengPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.ORCID 0000-0002-7403-8402
Pei LuoDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-8983-9229
Valeria C Torres IrizarryDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-6976-9673
Leslie Carrillo-SáenzDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-0152-7317
Meng YuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0002-8007-3378
Yongjie YangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0002-2354-4727
Benjamin P EappenChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Marcos David MunozDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-4126-1720
Nirali PatelDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-1400-4398
Sarah SchaulDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-9951-7733
Lucas IbrahimiDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-8122-5305
Penghua LaiDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-6119-8194
Xinyue QiSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 639798, Singapore.ORCID 0000-0001-5331-5274
Yuliang ZhouSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 639798, Singapore.ORCID 0009-0003-7277-0813
Maya KotaDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Devin DixitDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-9591-2173
Madeline MunDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Chong Wee LiewDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-9904-0958
Yuwei JiangDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-5082-8012
Chunmei WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0001-8104-6892
Yanlin HePennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.ORCID 0000-0002-5471-9016
Pingwen XuDivision of Endocrinology, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-9363-4114
Funding
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI RONALD N COHEN · 2013 to 2026
$20.9MThe role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI David H Burk · 2020 to 2026
$18.4MAlcohol Research Training in epigenetics and pathophysiology (ARTEP)T32AA026577 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SUBHASH C. PANDEY · 2019 to 2026
$2.7MRegulation of beige adipocyte maintenance and its impact on metabolic outcomesR01DK132398 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Yuwei Jiang · 2022 to 2026
$2.6MTestosterone and estrogen signaling pathways in the medial amygdala interact to control energy homeostasisR01DK123098 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XU, PINGWEN · 2020 to 2024
$2.5MGABA neurons in the ventromedial hypothalamus contribute to the counterregulatory responseR01DK129548 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Yanlin He · 2022 to 2026
$2.1MEMC10, a novel obesity-regulated circulating factor, regulates energy and metabolic homeostasisR01DK109015 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIEW, CHONG WEE · 2016 to 2020
$1.8MESTROGEN-INDUCIBLE PNNS ENHANCE EXCITATORY SYNAPTIC STRENGTH ONTO GABA NEURONS IN THE MEPD TO PREVENT OBESITY AND METABOLIC DYSREGULATIONR01DK136627 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Chunmei Wang · 2023 to 2026
$1.8MA TAP63 TRANSCRIPTIONAL AXIS CONTRIBUTES TO THE SEXUAL DIMORPHISM IN POMC NEURON FUNCTIONS AND ENERGY HOMEOSTASISK01DK119471 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WANG, CHUNMEI · 2019 to 2021
$391kEstrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic AdaptationF31DK132918 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TORRES IRIZARRY, VALERIA CECILIA · 2023 to 2024
$97kNIAAA NIH HHS T32 AA026577NIDDK NIH HHS F31 DK132918NIDDK NIH HHS K01 DK119471NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK109015NIDDK NIH HHS R01 DK123098NIDDK NIH HHS R01 DK129548NIDDK NIH HHS R01 DK132398NIDDK NIH HHS R01 DK136627NIGMS NIH HHS P20 GM135002
Abstract
Oxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize that 27HC binds to the estrogen receptor α (ERα) in the brain to regulate energy balance. Supporting this view, we found that delivering 27HC to the brain reduced food intake and activated proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (POMC
Indexed as
Arcuate Nucleus of HypothalamusFeeding BehaviorHydroxycholesterolsNeuronsAnimalsEstrogen Receptor alphaFemaleMicePro-Opiomelanocortin27-hydroxycholesterolEstrogen Receptor alphaHydroxycholesterolsPro-Opiomelanocortin
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What Socratic holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.