Evidence map›Paper›PMID 38999870›Full record

ArticleNutrients2024

Timut Pepper Extract Slows Age-Dependent Decline of Mobility and Collagen Loss and Promotes Longevity.

Elisabeth Jongsma, Giovanna Grigolon, Julia Baumann, David Weinkove, Collin Y Ewald, Franziska Wandrey, Torsten Grothe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elisabeth JongsmaLaboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, 8603 Schwerzenbach, Switzerland.
Giovanna GrigolonMibelle Group Biochemistry, Mibelle AG, 5033 Buchs, Switzerland.ORCID 0000-0002-0838-8826
Julia BaumannMibelle Group Biochemistry, Mibelle AG, 5033 Buchs, Switzerland.ORCID 0000-0001-5224-2093
David WeinkoveMagnitude Biosciences Ltd., NETPark Plexus, Thomas Wright Way, Sedgefield TS21 3FD, UK.
Collin Y EwaldLaboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, 8603 Schwerzenbach, Switzerland.ORCID 0000-0003-1166-4171
Franziska WandreyMibelle Group Biochemistry, Mibelle AG, 5033 Buchs, Switzerland.ORCID 0000-0002-1296-4021
Torsten GrotheMibelle Group Biochemistry, Mibelle AG, 5033 Buchs, Switzerland.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Investigations into human longevity are increasingly focusing on healthspan enhancement, not just lifespan extension. Lifestyle modifications and nutritional choices, including food supplements, can significantly affect aging and general health. Phytochemicals in centenarians' diets, such as those found in Timut pepper, a Nepalese spice with various medicinal properties, may contribute to their longevity. Similarly, Sichuan pepper, a related species, has demonstrated anti-inflammatory and neuroprotective activities. With the broader purpose of uncovering a novel treatment to address aging and its comorbidities, this study aims to investigate the potential lifespan- and healthspan-promoting effects of Timut pepper using the model organism

Indexed as

Caenorhabditis elegansCapsicumCollagenLongevityPlant ExtractsAgingAnimalsCaenorhabditis elegans ProteinsExtracellular MatrixCaenorhabditis elegans ProteinsCollagenPlant Extractsagingcognitionextracellular matrixhealthspanhydroxy-α-sanshoollifespanmovementspeedspicesupplement

Identifiers

PMID38999870
PMCPMC11243454

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.