Evidence map›Paper›PMID 38999941›Full record

ArticleInternational journal of molecular sciences2024

Association between Circulating T Cells and the Gut Microbiome in Healthy Individuals: Findings from a Pilot Study.

Sithara Vivek, You Shan Shen, Weihua Guan, Guillaume Onyeaghala, Mosunmoluwa Oyenuga, Christopher Staley, Amy B Karger, Anna E Prizment, Bharat Thyagarajan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Effect of dietary supplementation withFrontiers in veterinary science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sithara VivekDepartment of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware Street, Minneapolis, MN 55455, USA.
You Shan ShenDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Weihua GuanDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-0956-9821
Guillaume OnyeaghalaHennepin Healthcare Research Institute (HHRI), Minneapolis, MN 55404, USA.
Mosunmoluwa OyenugaDepartment of Internal Medicine, Abbott Northwestern Hospital, Minneapolis, MN 55407, USA.
Christopher StaleyDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2309-0083
Amy B KargerDepartment of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware Street, Minneapolis, MN 55455, USA.
Anna E PrizmentDepartment of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware Street, Minneapolis, MN 55455, USA.ORCID 0000-0001-5924-6871
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware Street, Minneapolis, MN 55455, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
National Institutes of Health's National Center for Advancing Translational Sciences UL1TR002494NCATS NIH HHS UL1 TR002494University of Minnesota Grant-in-Aid of Research, Artistry, and Scholarship program X
6 · The paper itself

Abstract

Though the microbiome's impact on immune system homeostasis is well documented, the effect of circulating T cells on the gut microbiome remains unexamined. We analyzed data from 50 healthy volunteers in a pilot trial of aspirin, using immunophenotyping and 16S rRNA sequencing to evaluate the effect of baseline T cells on microbiome changes over 6 weeks. We employed an unsupervised sparse canonical correlation analysis (sCCA) and used multivariable linear regression models to evaluate the association between selected T cell subsets and selected bacterial genera after adjusting for covariates. In the cross-sectional analysis, percentages of naïve CD4+ T cells were positively associated with a relative abundance of

Indexed as

Gastrointestinal MicrobiomeHealthy VolunteersRNA, Ribosomal, 16SAdultBacteriaCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCross-Sectional StudiesFemaleHumansMaleMiddle AgedPilot ProjectsT-LymphocytesT-Lymphocyte SubsetsRNA, Ribosomal, 16Shealthy gutmicrobiomeT cells

Identifiers

PMID38999941
PMCPMC11241708

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.