Evidence mapPaperPMID 38999980Full record

ArticleInternational journal of molecular sciences2024

LPA-Induced Thromboxane A2-Mediated Vasoconstriction Is Limited to Poly-Unsaturated Molecular Species in Mouse Aortas.

Krisztina Vén, Balázs Besztercei, Anna Janovicz, Noémi Karsai, Jerold Chun, Gábor Tigyi, Zoltán Benyó, Éva Ruisanchez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Krisztina VénInstitute of Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.
Balázs BeszterceiInstitute of Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-5636-284X
Anna JanoviczInstitute of Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.
Noémi KarsaiInstitute of Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0009-0000-3948-4071
Jerold ChunSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-3964-0921
Gábor TigyiInstitute of Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0001-5371-171X
Zoltán BenyóInstitute of Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0001-6015-0359
Éva RuisanchezInstitute of Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0001-7779-226X

Funding

Hungarian National Research, Development, and Innovation Office K-125174, PD-132851, K-135683, K-139230, NVKP_16-1-2016-0042, EFOP-3.6.3-VEKOP-16-2017-00009Ministry for Innovation and Technology from the Hungarian NRDI Fund 2020-1.1.6-JÖVŐ-2021-00010; 2020-1.1.6-JÖVŐ-2021-00013; TKP2021-EGA-25
6 · The paper itself

Abstract

We have previously reported that, in aortic rings, 18:1 lysophosphatidic acid (LPA) can induce both vasodilation and vasoconstriction depending on the integrity of the endothelium. The predominant molecular species generated in blood serum are poly-unsaturated LPA species, yet the vascular effects of these species are largely unexplored. We aimed to compare the vasoactive effects of seven naturally occurring LPA species in order to elucidate their potential pathophysiological role in vasculopathies. Vascular tone was measured using myography, and thromboxane A

Indexed as

AortaLysophospholipidsMice, Inbred C57BLThromboxane A2VasoconstrictionAnimalsCalciumEndothelial CellsMaleMiceVasodilationCalciumlysophosphatidic acidLysophospholipidsThromboxane A2lysophosphatidic acidlysophosphatidic acid receptor 1thromboxanevasoconstriction

Identifiers

PMID38999980
PMCPMC11241118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.