Evidence map›Paper›PMID 39000234›Full record

ArticleInternational journal of molecular sciences2024

Decreased Peripheral Blood Natural Killer Cell Count in Untreated Juvenile Dermatomyositis Is Associated with Muscle Weakness.

Amer Khojah, Lauren M Pachman, Ameera Bukhari, Chi Trinh, Gabrielle Morgan, Surya Pandey, I Caroline Le Poole, Marisa S Klein-Gitelman

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amer KhojahDepartment of Pediatrics, College of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0003-3357-4863
Lauren M PachmanDivision of Pediatric Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Box 50, Chicago, IL 60611, USA.ORCID 0000-0001-8117-574X
Ameera BukhariCollege of Science, Taif University, Taif 21944, Saudi Arabia.
Chi TrinhDivision of Pediatric Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Box 50, Chicago, IL 60611, USA.ORCID 0009-0005-1787-899X
Gabrielle MorganDivision of Pediatric Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Box 50, Chicago, IL 60611, USA.ORCID 0000-0002-4058-7112
Surya PandeyRobert H. Lurie Comprehensive Cancer Center, Skin Biology and Diseases Resource-Based Center, Chicago, IL 60611, USA.
I Caroline Le PooleFeinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-6853-4007
Marisa S Klein-GitelmanDivision of Pediatric Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Box 50, Chicago, IL 60611, USA.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Northwestern University Skin Disease Research Center Resource-based CenterP30AR075049 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Amy S Paller · 2019 to 2026
$6.6M
Mitochondrial calcification in juvenile dermatomyositisR21AR077565 · NIAMS · UNIVERSITY OF WASHINGTON · PI LOOD, JAN CHRISTIAN · 2020 to 2021
$432k
CureJM Foundation n/aDenUyl Family Fund n/aNCATS NIH HHS UL1 TR001422NIAMS NIH HHS P30 AR075049NIAMS NIH HHS R21 AR077565NIH HHS 1R21 AR077565NIH HHS UL1TR001422
6 · The paper itself

Abstract

Juvenile Dermatomyositis (JDM) is the most common inflammatory myopathy in pediatrics. This study evaluates the role of Natural Killer (NK) cells in Juvenile Dermatomyositis (JDM) pathophysiology. The study included 133 untreated JDM children with an NK cell count evaluation before treatment. NK cell subsets (CD56

Indexed as

CD56 AntigenDermatomyositisKiller Cells, NaturalMuscle WeaknessAdolescentChildChild, PreschoolFemaleHumansLymphocyte CountMalePerforinCD56 AntigenNCAM1 protein, humanPerforindisease activity scoresjuvenile dermatomyositisnatural killer cellperforin expression

Identifiers

PMID39000234
PMCPMC11241205

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.