Evidence map›Paper›PMID 39000274›Full record

ArticleInternational journal of molecular sciences2024

Analysis of Expression of the ANG1, CaSR and FAK Proteins in Uterine Fibroids.

Anna Markowska, Mateusz de Mezer, Paweł Kurzawa, Wiesława Bednarek, Anna Gryboś, Monika Krzyżaniak, Janina Markowska, Marian Gryboś, Jakub Żurawski

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna MarkowskaDepartment of Perinatology and Women's Diseases, Poznan University of Medical Sciences, 60-535 Poznan, Poland.
Mateusz de MezerMedical Biology, Department of Immunobiology, Poznan University of Medical Sciences, 60-806 Poznan, Poland.ORCID 0000-0003-4718-9747
Paweł KurzawaDepartment of Clinical Pathology and Immunology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.ORCID 0000-0002-2223-0291
Wiesława BednarekDepartment of Oncological Gynecology and Gynecology, Medical University of Lublin, 20-059 Lublin, Poland.
Anna GrybośDepartment of Gynecology and Obstetrics, Faculty of Health Sciences, Wroclaw Medical University, 50-367 Wroclaw, Poland.ORCID 0000-0003-3677-3374
Monika KrzyżaniakDepartment of Clinical Pathology and Immunology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.ORCID 0000-0003-0375-9920
Janina MarkowskaGynecological Center, 60-560 Poznan, Poland.
Marian GrybośInstitute of Health Sciences, University of Opole, 45-040 Opole, Poland.
Jakub ŻurawskiMedical Biology, Department of Immunobiology, Poznan University of Medical Sciences, 60-806 Poznan, Poland.ORCID 0000-0002-5838-0451

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the molecular factors involved in the development of uterine myomas may result in the use of pharmacological drugs instead of aggressive surgical treatment. ANG1, CaSR, and FAK were examined in myoma and peripheral tissue samples taken from women after myoma surgery and in normal uterine muscle tissue samples taken from the control group. Tests were performed using tissue microarray immunohistochemistry. No statistically significant differences in ANG1 expression between the tissue of the myoma, the periphery, and the normal uterine muscle tissue of the control group were recorded. The CaSR value was reduced in the myoma and peripheral tissue and normal in the group of women without myomas. FAK expression was also lower in the myoma and periphery compared to the healthy uterine myometrium. Calcium supplementation could have an effect on stopping the growth of myomas.

Indexed as

Focal Adhesion Kinase 1LeiomyomaReceptors, Calcium-SensingUterine NeoplasmsAdultAngiopoietin-1FemaleHumansImmunohistochemistryMiddle AgedMyometriumAngiopoietin-1ANGPT1 protein, humanCASR protein, humanFocal Adhesion Kinase 1PTK2 protein, humanReceptors, Calcium-Sensingangiopoietin 1calcium sensing receptorfocal adhesion kinaseuterine myoma

Identifiers

PMID39000274
PMCPMC11241732

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.