Evidence map›Paper›PMID 39000409›Full record

ArticleInternational journal of molecular sciences2024

Pirfenidone Prevents Heart Fibrosis during Chronic Chagas Disease Cardiomyopathy.

Tatiana Araújo Silva, Diane Thomas, Jair L Siqueira-Neto, Claudia Magalhaes Calvet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Molecular mechanisms of ovarian fibrosis.Molecular human reproduction · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tatiana Araújo SilvaCellular Ultrastructure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro 21040-360, RJ, Brazil.
Diane ThomasCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Jair L Siqueira-NetoCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9574-8174
Claudia Magalhaes CalvetCellular Ultrastructure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro 21040-360, RJ, Brazil.

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Binhai Zheng · 2003 to 2021
$2.9M
NINDS NIH HHS P30 NS047101University of California, San Diego RQ276RCALVET ALVAREZ
6 · The paper itself

Abstract

Cardiac fibrosis is a severe outcome of Chagas disease (CD), caused by the protozoan

Indexed as

Chagas CardiomyopathyFibrosisMice, Inbred C57BLPyridonesAnimalsAnthracenesChronic DiseaseCollagenDisease Models, AnimalFibroblastsHumansMaleMiceMyocardiump38 Mitogen-Activated Protein KinasesTransforming Growth Factor betaAnthracenesCollagenp38 Mitogen-Activated Protein KinasespirfenidonepyrazolanthronePyridonesTransforming Growth Factor betaChagas diseaseheart fibrosispirfenidone

Identifiers

PMID39000409
PMCPMC11242150

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.