ArticleInternational journal of molecular sciences2024
Loss of Mitochondrial Tusc2/Fus1 Triggers a Brain Pro-Inflammatory Microenvironment and Early Spatial Memory Impairment.
Tonie Farris, Salvador González-Ochoa, Muna Mohammed, Harshana Rajakaruna, Jane Tonello, Thanigaivelan Kanagasabai, Olga Korolkova, Akiko Shimamoto, Alla Ivanova, Anil Shanker
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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5 · Who and what moneyAuthors and funding
10 authors.
Tonie FarrisDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208, USA.
Salvador González-OchoaDepartment of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.ORCID 0000-0002-5787-4759 Muna MohammedDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208, USA.
Harshana RajakarunaThe Office for Research and Innovation, Meharry Medical College, Nashville, TN 37208, USA.
Jane TonelloDepartment of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
Thanigaivelan KanagasabaiDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208, USA.ORCID 0000-0002-9867-8076 Olga KorolkovaDepartment of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
Akiko ShimamotoDepartment of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
Alla IvanovaDepartment of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208, USA.ORCID 0000-0002-4149-5105 Anil ShankerDepartment of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.ORCID 0000-0001-6372-3669 Funding
AIM-AHEAD Coordinating Center - All Four CoresOT2OD032581 · OD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Paul Avillach, Bettina M. Beech · 2021 to 2026
$168.7MEndowment for Health Disparities ResearchS21MD000104 · NIMHD · MEHARRY MEDICAL COLLEGE · PI HILDRETH, JAMES E · 2001 to 2016
$73.1MThe RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Samuel Evans Adunyah, JAMES E HILDRETH · 2017 to 2026
$48.2MTechnologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7MTHE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0MTranslational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2011 to 2025
$18.8MTECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54RR026140 · NCRR · MEHARRY MEDICAL COLLEGE · PI MURRAY, JOHN J. · 2009 to 2011
$12.9MOverall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3MRole of Fus1-mediated antitumor CD8T-NK crosstalk in Alzheimer's disease pathologySC1CA182843 · NCI · MEHARRY MEDICAL COLLEGE · PI SHANKER, ANIL · 2013 to 2020
$3.1MDiversity Center for Genome Research at MeharryUG3HG013248 · NHGRI · MEHARRY MEDICAL COLLEGE · PI SHANKER, ANIL · 2023 to 2023
$866kNCI NIH HHS SC1 CA182843NCI NIH HHS U54 CA163069NCRR NIH HHS U54 RR026140NHGRI NIH HHS UG3 HG013248NICHD NIH HHS P50 HD103537NIGMS NIH HHS R25 GM059994NIH HHS OT2 OD032581NIMHD NIH HHS S21 MD000104NIMHD NIH HHS U54 MD007586NIMHD NIH HHS U54 MD007593
6 · The paper itselfAbstract
Brain pathological changes impair cognition early in disease etiology. There is an urgent need to understand aging-linked mechanisms of early memory loss to develop therapeutic strategies and prevent the development of cognitive impairment. Tusc2 is a mitochondrial-resident protein regulating Ca
Indexed as
MitochondriaSpatial MemoryAnimalsAstrocytesBrainCellular MicroenvironmentFemaleHippocampusInflammationMaleMembrane ProteinsMemory DisordersMiceMice, Inbred C57BLMice, KnockoutMitochondrial ProteinsMembrane ProteinsMitochondrial ProteinsTumor Suppressor ProteinsTusc2 protein, mouseagingbrain immune populationscalciumcognitive impairmentFus1mitochondrianeuroinflammationsex-dependent changesTusc2
Identifiers
PMID39000512
PMCPMC11242373
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