Evidence map›Paper›PMID 39000568›Full record

ArticleInternational journal of molecular sciences2024

Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model.

Hongri Ruan, Tingting Zhu, Tiantian Wang, Yingchao Guo, Yun Liu, Jiasan Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongri RuanCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Tingting ZhuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Tiantian WangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Yingchao GuoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Yun LiuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Jiasan ZhengCollege of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163000, China.

Funding

National Natural Science Foundation of China 32172931National Natural Science Foundation of China 32373083
6 · The paper itself

Abstract

Osteoarthritis (OA) is the most common joint disease, causing symptoms such as joint pain, swelling, and deformity, which severely affect patients' quality of life. Despite advances in medical treatment, OA management remains challenging, necessitating the development of safe and effective drugs. Quercetin (QUE), a natural flavonoid widely found in fruits and vegetables, shows promise due to its broad range of pharmacological effects, particularly in various degenerative diseases. However, its role in preventing OA progression and its underlying mechanisms remain unclear. In this study, we demonstrated that QUE has a protective effect against OA development both in vivo and in vitro, and we elucidated the underlying molecular mechanisms. In vitro, QUE inhibited the expression of IL-1β-induced chondrocyte matrix metalloproteinases (MMP3 and MMP13) and inflammatory mediators such as INOS and COX-2. It also promoted the expression of collagen II, thereby preventing the extracellular matrix (ECM). Mechanistically, QUE exerts its protective effect on chondrocytes by activating the SIRT1/Nrf-2/HO-1 and inhibiting chondrocyte ferroptosis. Similarly, in an OA rat model induced by anterior cruciate ligament transection (ACLT), QUE treatment improved articular cartilage damage, reduced joint pain, and normalized abnormal subchondral bone remodeling. QUE also reduced serum IL-1β, TNF-α, MMP3, CTX-II, and COMP, thereby slowing the progression of OA. QUE exerts chondroprotective effects by inhibiting chondrocyte oxidative damage and ferroptosis through the SIRT1/Nrf-2/HO-1 pathway, effectively alleviating OA progression in rats.

Indexed as

Cartilage, ArticularChondrocytesDisease Models, AnimalFerroptosisNF-E2-Related Factor 2OsteoarthritisQuercetinSirtuin 1AnimalsHeme Oxygenase (Decyclizing)Interleukin-1betaMaleRatsRats, Sprague-DawleySignal TransductionHeme Oxygenase (Decyclizing)Hmox1 protein, ratInterleukin-1betaNfe2l2 protein, ratNF-E2-Related Factor 2QuercetinSirt1 protein, ratSirtuin 1ECMferroptosisosteoarthritisoxidative stressquercetin

Identifiers

PMID39000568
PMCPMC11242395

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.