Evidence map›Paper›PMID 39002453›Full record

ArticlePsychoneuroendocrinology2024

Salivary uric acid dynamics are associated with stress response hormones among African Americans in an urban sample.

Stefan M M Goetz, Todd Lucas, Douglas A Granger

Abstract read
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In one paragraph

Article in Psychoneuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stefan M M GoetzCharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, 200 East 1st Street, Flint, MI 48502, USA. Electronic address: goetzste@msu.edu.
Todd LucasCharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, 200 East 1st Street, Flint, MI 48502, USA. Electronic address: lucastod@msu.edu.
Douglas A GrangerDepartment of Psychological Science, School of Social Ecology, University of California at Irvine, Irvine, CA 92697-1075, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, 4201 SBSG, Irvine, CA 92697-7085, USA; John Hopkins University School of Medicine, 615 North Wolfe St., Baltimore, MD 21205, USA. Electronic address: dagrange@uci.edu.

Funding

Perceived Fairness and Biological Stress ReactivityR21HL097191 · NHLBI · WAYNE STATE UNIVERSITY · PI LUCAS, TODD WILLIAM · 2010 to 2011
$418k
NHLBI NIH HHS R21 HL097191
6 · The paper itself

Abstract

Acute physiological responses to psychosocial stressors are a potential pathway underlying racial disparities in stress-related illnesses. Uric acid (UA) is a potent antioxidant that has been linked to disparities in stress-related illnesses, and recent research has shown that UA is responsive to acute social stress. However, an examination of the relationships between the purinergic system and other commonly measured stress systems is lacking. Here, we measure and characterize associations of salivary uric acid (sUA) with markers of hypothalamic-pituitary-adrenal (HPA) axis activation, sympathetic-adreno-medullar (SAM) axis activation, and acute inflammation. A community sample of 103 African Americans (33 male, 70 female) completed the Trier Social Stress Test to induce social-evaluative threat. Passive drool collected before, during, and after the stressor task provided salivary reactivity measures of UA (sUA), cortisol, dehydroepiandrosterone sulfate (DHEAS), salivary alpha amylase (sAA - a surrogate marker of SAM activity) and C-reactive protein (sCRP). Multiple regressions revealed that total activation of cortisol, DHEAS, and sCRP were each positively associated with higher total activation of sUA. Additionally, DHEAS reactivity was positively associated with sUA reactivity. Relationships between HPA-axis markers and sUA were especially observed among younger and male participants. Overall, findings suggest potential coordination of stress systems with sUA in response to acute stress, which may further the contributions of biological stress processes to racial health disparities.

Indexed as

Black or African AmericanHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemStress, PsychologicalUric AcidAdultBiomarkersC-Reactive ProteinDehydroepiandrosterone SulfateFemaleHumansMaleMiddle AgedSalivaSalivary alpha-AmylasesBiomarkersC-Reactive ProteinDehydroepiandrosterone SulfateHydrocortisoneSalivary alpha-AmylasesUric AcidHealth DisparitiesMultisystem StressPurinergic Stress ResponseStress ReactivityTrier Social Stress TestUric Acid

Identifiers

PMID39002453
PMCPMC11317218

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.