Evidence map›Paper›PMID 39003094›Full record

ArticleAmerican journal of surgery2024

Phase I clinical trial of the feasibility and safety of direct peritoneal resuscitation in liver transplantation.

Ivan E Rodriguez, Zachary P Asher, Katherine Klingenberg, Franklin L Wright, Trevor L Nydam, Megan A Adams, Yanik J Bababekov, Eric Peltz, Jason W Smith, Jessica L Saben and 4 more

Abstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ivan E RodriguezColorado Center for Transplantation Care, Research, and Education (CCTCARE), Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Zachary P AsherDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Katherine KlingenbergColorado Center for Transplantation Care, Research, and Education (CCTCARE), Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Franklin L WrightDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Trevor L NydamColorado Center for Transplantation Care, Research, and Education (CCTCARE), Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Megan A AdamsColorado Center for Transplantation Care, Research, and Education (CCTCARE), Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Division of Transplant Surgery, Department of Surgery, Children's Hospital Colorado, Aurora, CO, USA.
Yanik J BababekovColorado Center for Transplantation Care, Research, and Education (CCTCARE), Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Eric PeltzDepartment of Surgery, Logan Health Medical Center, Kalispell, MT, USA.
Jason W SmithDepartment of Surgery, University of Louisville Health, Louisville, KY, USA.
Jessica L SabenColorado Center for Transplantation Care, Research, and Education (CCTCARE), Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Peter KennealeyColorado Center for Transplantation Care, Research, and Education (CCTCARE), Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
James J PomposelliColorado Center for Transplantation Care, Research, and Education (CCTCARE), Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Elizabeth A PomfretColorado Center for Transplantation Care, Research, and Education (CCTCARE), Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Hunter B MooreAdventHealth Transplant Institute at Porter, Denver, CO, USA. Electronic address: Hunter.Moore@adventhealth.com.

Funding

Fibrinolysis Dysfunction Impact on Graft Function in Liver TransplantationR00HL151887 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MOORE, HUNTER B · 2021 to 2023
$747k
NHLBI NIH HHS R00 HL151887
6 · The paper itself

Abstract

backgroundDirect peritoneal resuscitation (DPR) is associated with improved outcomes in trauma. Animal models suggest DPR has favorable effects on the liver. We sought to evaluate its safety and assess for improved outcomes in liver transplantation (LT).

methodsLT patients with renal dysfunction and/or obesity were enrolled in a phase-I clinical trial. DPR lasted 8-24 ​h depending on postoperative disposition. Primary outcome was percent of patients completing DPR. Secondary outcomes evaluated complications. Controls with either obesity (control-1) or both risk factors (obesity ​+ ​renal dysfunction, control-2) were analyzed.

resultsFifteen patients were enrolled (seven with both criteria and eight with obesity alone). DPR was completed in 87 ​% of patients, with one meeting stopping criteria. Controls included 45 (control-1) and 24 (control-2) patients. Return to operating room, graft loss, and late infections were lower with DPR.

conclusionDPR appears to be safe in closed abdomens following LT, warranting a follow-up phase-II trial to assess efficacy.

Indexed as

Feasibility StudiesLiver TransplantationResuscitationAdultAgedFemaleHumansMaleMiddle AgedObesityPostoperative ComplicationsTreatment OutcomeDirect peritoneal resuscitationGraft lossInfectionLiver transplantReturn to operating room

Identifiers

PMID39003094
PMCPMC11585457

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.