ArticleJournal of neuroengineering and rehabilitation2024
Inter-joint coordination with and without dopaminergic medication in Parkinson's disease: a case-control study.
Article in Journal of neuroengineering and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Quantitative Assessment of Lower-Limb Multi-joint Synergy in Knee Osteoarthritis by Integrating Spatiotemporal Dual-Topology Features Under the HSMR Framework.Annals of biomedical engineering · 2026Article
- Whole body analysis of functional communities and topological features of gait with different speeds in Parkinson's disease.Journal of neurology · 2026Article
- Body placement of inertial measurement units differentially affects physical activity assessment accuracy in drug-naïve Parkinson's disease.Scientific reports · 2026Article
- Application of a spatiotemporal distribution-based multidimensional gait feature algorithm in KOA gait assessment.Medical & biological engineering & computing · 2026Article
- Cyclogram analysis of canine gait: quantifying inter-joint coordination and clinical utility in rehabilitation.Frontiers in veterinary science · 2026Article
- Multimodal Motion Capture Toolbox for Enhanced Analysis of Intersegmental Coordination in Children with Cerebral Palsy and Typically Developing.Journal of visualized experiments : JoVE · 2025Article
- Inter-segmental coordination patterns in Parkinson's disease are particularly disturbed during preferred walking speed: a data-driven network approach.Journal of neuroengineering and rehabilitation · 2025Article
- Bridging the Methodological Gap Between Inertial Sensors and Optical Motion Capture: Deep Learning as the Path to Accurate Joint Kinematic Modelling Using Inertial Sensors.Sensors (Basel, Switzerland) · 2025Article
- Influence of Gait Speed on Inter-Joint Coordination in People with and Without Parkinson's Disease.Biosensors · 2025Article
- Application of multidimensional gait feature fusion algorithm in gait assessment for patients with knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2025Article
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Authors and funding
6 authors.
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Abstract
backgroundHow the joints exactly move and interact and how this reflects PD-related gait abnormalities and the response to dopaminergic treatment is poorly understood. A detailed understanding of these kinematics can inform clinical management and treatment decisions. The aim of the study was to investigate the influence of different gait speeds and medication on/off conditions on inter-joint coordination, as well as kinematic differences throughout the whole gait cycle in well characterized pwPD.
methods29 controls and 29 PD patients during medication on, 8 of them also during medication off walked a straight walking path in slow, preferred and fast walking speeds. Gait data was collected using optical motion capture system. Kinematics of the hip and knee and coordinated hip-knee kinematics were evaluated using Statistical Parametric Mapping (SPM) and cyclograms (angle-angle plots). Values derived from cyclograms were compared using repeated-measures ANOVA for within group, and ttest for between group comparisons.
resultsPD gait differed from controls mainly by lower knee range of motion (ROM). Adaptation to gait speed in PD was mainly achieved by increasing hip ROM. Regularity of gait was worse in PD but only during preferred speed. The ratios of different speed cyclograms were smaller in the PD groups. SPM analyses revealed that PD participants had smaller hip and knee angles during the swing phase, and PD participants reached peak hip flexion later than controls. Withdrawal of medication showed an exacerbation of only a few parameters.
conclusionsOur findings demonstrate the potential of granular kinematic analyses, including > 1 joint, for disease and treatment monitoring in PD. Our approach can be extended to further mobility-limiting conditions and other joint combinations.
trial registrationThe study is registered in the German Clinical Trials Register (DRKS00022998, registered on 04 Sep 2020).
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