Evidence map›Paper›PMID 39003487›Full record

ArticleRespiratory research2024

Midregional Proatrial Natriuretic Peptide (MRproANP) is associated with vertebral fractures and low bone density in patients with chronic obstructive pulmonary disease (COPD).

Franziska C Trudzinski, Rudolf A Jörres, Peter Alter, Henrik Watz, Claus F Vogelmeier, Hans-Ulrich Kauczor, Subasini Thangamani, Manuel Debic, Tobias Welte, Jürgen Behr and 13 more

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01245933 (Impact of Systemic Manifestations/Comorbidities on Clinical State, Prognosis and Utilisation of Health Care Resources in Patients With COPD), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01245933 completednot on this map

Impact of Systemic Manifestations/Comorbidities on Clinical State, Prognosis and Utilisation of Health Care Resources in Patients With COPD

TypeobservationalSponsorPhilipps University MarburgRan2010 to 2023Enrolled2,741ConditionsChronic Obstructive Pulmonary Disease (COPD)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Franziska C TrudzinskiDepartment of Pneumology and Critical Care Medicine), German Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC-H), Thoraxklinik University of Heidelberg, Röntgenstrasse 1, 69126, Heidelberg, Germany. Franziska.trudzinski@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-0980-7586
Rudolf A JörresInstitute and Outpatient Clinic for Occupational, Social and Environmental Medicine, German Center for Lung Research (DZL), LMU University Hospital, Ludwig-Maximilians-University (LMU), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany.
Peter AlterDepartment of Medicine, Pulmonary and Critical Care Medicine, German Center for Lung Research (DZL), Philipps University of Marburg (UMR), Marburg, Germany.
Henrik WatzPulmonary Research Institute at LungenClinic Grosshansdorf, Grosshansdorf, Germany.
Claus F VogelmeierDepartment of Medicine, Pulmonary and Critical Care Medicine, German Center for Lung Research (DZL), Philipps University of Marburg (UMR), Marburg, Germany.
Hans-Ulrich KauczorDepartment of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Subasini ThangamaniDepartment of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Manuel DebicDepartment of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Tobias WelteDepartment of Pneumology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Jürgen BehrDepartment of Internal Medicine V, CPC Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), University Hospital, LMU Munich, Munich, Germany.
Kathrin KahnertDepartment of Internal Medicine V, CPC Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), University Hospital, LMU Munich, Munich, Germany.
Robert BalsDepartment of Internal Medicine V - Pulmonology, Allergology, Critical Care Care Medicine, Saarland University Hospital, Homburg, Germany.
Christian HerrDepartment of Internal Medicine V - Pulmonology, Allergology, Critical Care Care Medicine, Saarland University Hospital, Homburg, Germany.
Claus Peter HeußelGerman Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany.
Jürgen BiedererDepartment of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Oyunbileg von StackelbergDepartment of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Sebastian FähndrichDepartment of Pneumology, University Medical Centre Freiburg, Freiburg, Germany.
Emiel F M WoutersDepartment of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Benjamin WaschkiLungenClinic Grosshansdorf, Airway Research Center North, Member of the German Center for Lung Research, Pulmonary Research Institute, Woehrendamm 80, 22927, Grosshansdorf, Germany.
Klaus F RabeLungenClinic Grosshansdorf, Airway Research Center North, Member of the German Center for Lung Research, Pulmonary Research Institute, Woehrendamm 80, 22927, Grosshansdorf, Germany.
Felix J F HerthDepartment of Pneumology and Critical Care Medicine), German Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC-H), Thoraxklinik University of Heidelberg, Röntgenstrasse 1, 69126, Heidelberg, Germany.
Viktoria PalmDepartment of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
COSYCONET study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with COPD are often affected by loss of bone mineral density (BMD) and osteoporotic fractures. Natriuretic peptides (NP) are known as cardiac markers, but have also been linked to fragility-associated fractures in the elderly. As their functions include regulation of fluid and mineral balance, they also might affect bone metabolism, particularly in systemic disorders such as COPD. RESEARCH QUESTION: We investigated the association between NP serum levels, vertebral fractures and BMD assessed by chest computed tomography (CT) in patients with COPD.

methodsParticipants of the COSYCONET cohort with CT scans were included. Mean vertebral bone density on CT (BMD-CT) as a risk factor for osteoporosis was assessed at the level of TH12 (AI-Rad Companion), and vertebral compression fractures were visually quantified by two readers. Their relationship with N-terminal pro-B-type natriuretic peptide (NT-proBNP), Mid-regional pro-atrial natriuretic peptide (MRproANP) and Midregional pro-adrenomedullin (MRproADM) was determined using group comparisons and multivariable analyses.

resultsAmong 418 participants (58% male, median age 64 years, FEV

interpretationMRproANP was a marker for osteoporotic vertebral fractures in our COPD patients from the COSYCONET cohort. Its association with reduced vertebral BMD on CT and its known modulating effects on fluid and ion balance are suggestive of direct effects on bone mineralization.

trial registrationClinicalTrials.gov NCT01245933, Date of registration: 18 November 2010.

Indexed as

Atrial Natriuretic FactorBiomarkersBone DensityPulmonary Disease, Chronic ObstructiveSpinal FracturesAgedCohort StudiesFemaleHumansMaleMiddle AgedOsteoporotic FracturesProtein PrecursorsAtrial Natriuretic FactorBiomarkersmidregional pro-atrial natriuretic peptide, humanProtein Precursors

Identifiers

PMID39003487
PMCPMC11245771

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.