Evidence map›Paper›PMID 39005213›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2024

Novel Metabolites Associated With Blood Pressure After Dietary Interventions.

Yixi Sun, Ruiyuan Zhang, Ling Tian, Yang Pan, Xiao Sun, Zhijie Huang, Jia Fan, Jing Chen, Kai Zhang, Shengxu Li and 6 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yixi SunDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).
Ruiyuan ZhangDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).ORCID 0000-0002-4639-3300
Ling TianDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).ORCID 0000-0002-8521-9575
Yang PanDivision of Nephrology, Department of Medicine, College of Medicine, University of Illinois at Chicago (Y.P., X.S., T.N.K.).ORCID 0000-0003-3487-7233
Xiao SunDivision of Nephrology, Department of Medicine, College of Medicine, University of Illinois at Chicago (Y.P., X.S., T.N.K.).ORCID 0000-0001-8802-2957
Zhijie HuangDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).
Jia FanDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).ORCID 0000-0003-3384-0834
Jing ChenDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).ORCID 0000-0002-9035-9126
Kai ZhangDepartment of Environmental Health Sciences, University of Albany, State University of New York, Rensselaer (K.Z.).ORCID 0000-0003-0393-5955
Shengxu LiChildren's Minnesota Research Institute, Children's Minnesota, Minneapolis (S.L.).ORCID 0000-0001-9210-7283
Wei ChenDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).ORCID 0000-0003-1566-7943
Lydia A BazzanoDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).ORCID 0000-0002-8958-1352
Tanika N KellyDivision of Nephrology, Department of Medicine, College of Medicine, University of Illinois at Chicago (Y.P., X.S., T.N.K.).ORCID 0000-0002-7348-4451
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).ORCID 0000-0002-8286-9652
Joshua D BundyDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).ORCID 0000-0002-6054-2624
Changwei LiDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.S., R.Z., L.T., Z.H., J.F., J.C., W.C., L.B., J.H., J.D.B., C.L.).ORCID 0000-0002-9203-304X

Funding

Tulane COBRE for Clinical and Translational Research in Cardiometabolic DiseasesP20GM109036 · TULANE UNIVERSITY OF LOUISIANA · 2025 to 2025
$2.2M
NHLBI NIH HHS R21 HL161718NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

backgroundThe blood pressure (BP) etiologic study is complex due to multifactorial influences, including genetic, environmental, lifestyle, and their intricate interplays. We used a metabolomics approach to capture internal pathways and external exposures and to study BP regulation mechanisms after well-controlled dietary interventions.

methodsIn the ProBP trail (Protein and Blood Pressure), a double-blinded crossover randomized controlled trial, participants underwent dietary interventions of carbohydrate, soy protein, and milk protein, receiving 40 g daily for 8 weeks, with 3-week washout periods. We measured plasma samples collected at baseline and at the end of each dietary intervention. Multivariate linear models were used to evaluate the association between metabolites and systolic/diastolic BP. Nominally significant metabolites were examined for enriching biological pathways. Significant ProBP findings were evaluated for replication among 1311 participants of the BHS (Bogalusa Heart Study), a population-based study conducted in the same area as ProBP.

resultsAfter Bonferroni correction for 77 independent metabolite clusters (α=6.49×10

conclusionsSeven novel metabolites were identified to be associated with BP at the end of different dietary interventions. The beneficial effects of protein interventions might be mediated through specific metabolic pathways.

Indexed as

Blood PressureCross-Over StudiesHypertensionAdultDietary CarbohydratesDouble-Blind MethodFemaleHumansMaleMetabolomicsMiddle AgedDietary Carbohydratesblood pressurecarbohydratesincretinsmaltosemilk proteinsseleniumsoybean proteins

Identifiers

PMID39005213
PMCPMC11324412

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.