Evidence map›Paper›PMID 39005335›Full record

ArticlebioRxiv : the preprint server for biology2024

Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion.

Abdul Hannan, Qian Wang, Yihua Wu, Neoklis Makrides, Xiuxia Qu, Junhao Mao, Jianwen Que, Wellington Cardoso, Xin Zhang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdul HannanDepartment of Ophthalmology, Columbia University, New York, NY 10032, USA.
Qian WangDepartment of Ophthalmology, Columbia University, New York, NY 10032, USA.
Yihua WuDepartment of Ophthalmology, Columbia University, New York, NY 10032, USA.
Neoklis MakridesDepartment of Ophthalmology, Columbia University, New York, NY 10032, USA.
Xiuxia QuWuxi School of Medicine, Jiangnan University, Wuxi, China.
Junhao MaoDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jianwen QueColumbia Center for Human Development, Columbia University, New York, NY, USA.
Wellington CardosoColumbia Center for Human Development, Columbia University, New York, NY, USA.
Xin ZhangDepartment of Ophthalmology, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-5555-0825

Funding

Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
Regulation of FGF signaling in lacrimal gland developmentR01EY018868 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI Xin Zhang · 2009 to 2026
$6.3M
VEGF/KDR Signaling in Airway Epithelial Regeneration and DiseaseR01HL152293 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.0M
Mechanism of Csk signaling in lacrimal gland morphogenesisR01EY031210 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHANG, XIN · 2020 to 2023
$1.6M
Signaling networks and transcriptional programs in lens vesicle formationK99EY032171 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, QIAN · 2022 to 2023
$237k
NEI NIH HHS K99 EY032171NEI NIH HHS P30 EY019007NEI NIH HHS R01 EY018868NEI NIH HHS R01 EY031210NHLBI NIH HHS R01 HL152293
6 · The paper itself

Abstract

Src family kinases (SFKs), including Src, Fyn and Yes, play important roles in development and cancer. Despite being first discovered as the Yes-associated protein, the regulation of Yap by SFKs remains poorly understood. Here, through single-cell analysis and genetic lineage tracing, we show that the pan-epithelial ablation of C-terminal Src kinase (Csk) in the lacrimal gland unleashes broad Src signaling but specifically causes extrusion and apoptosis of acinar progenitors at a time when they are shielded by myoepithelial cells from the basement membrane.

Indexed as

cell extrusionlacrimal glandRac1Rap1SrcYap

Identifiers

PMID39005335
PMCPMC11244872

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.