Evidence map›Paper›PMID 39005359›Full record

ArticlebioRxiv : the preprint server for biology2024

Gene expression asymmetry in Parkinson's Disease; variation of

Steven E Pierce, Edwin J C van der Schans, Elizabeth Ensink, Gerhard A Coetzee

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Steven E PierceVan Andel Institute, Grand Rapids, Michigan, USA.ORCID 0000-0002-7417-2302
Edwin J C van der SchansVan Andel Institute, Grand Rapids, Michigan, USA.
Elizabeth EnsinkVan Andel Institute, Grand Rapids, Michigan, USA.
Gerhard A CoetzeeVan Andel Institute, Grand Rapids, Michigan, USA.ORCID 0000-0001-8820-8364

Funding

Epigenetic contributions to symptom asymmetry in Parkinson's diseaseR01NS113894 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI COETZEE, GERHARD A · 2020 to 2024
$2.2M
NINDS NIH HHS R01 NS113894
6 · The paper itself

Abstract

Parkinson's Disease (PD) develops unilaterally, which may be related to brain hemispheric differences in gene expression. Here we measured bulk RNA-seq levels in neuronal nuclei obtained from prefrontal cortex postmortem brain samples from males and females with PD and from healthy controls. Left and right hemispheres from each brain were related the side of symptom onset and compared. We employed two

Identifiers

PMID39005359
PMCPMC11245011

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.