Evidence map›Paper›PMID 39005405›Full record

ArticlebioRxiv : the preprint server for biology2024

IGF-1 Acts through Kiss1-expressing Cells to Influence Metabolism and Reproduction.

Mengjie Wang, Seamus M Pugh, Judy Daboul, David Miller, Yong Xu, Jennifer W Hill

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mengjie WangCenter for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, Ohio, USA.
Seamus M PughCenter for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, Ohio, USA.
Judy DaboulCenter for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, Ohio, USA.
David MillerCenter for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, Ohio, USA.
Yong XuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Jennifer W HillCenter for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, Ohio, USA.ORCID 0000-0001-7482-9215

Funding

Astrocyte insulin resistance-induced neuroendocrine defects in pubertal delay and hypogonadotropic hypogonadismR01HD104418 · NICHD · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI Jennifer Wootton Hill · 2022 to 2026
$2.7M
Nutrition Regulates Sexual FunctionF32HD112123 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI WANG, MENGJIE · 2024 to 2025
$131k
NICHD NIH HHS F32 HD112123NICHD NIH HHS R01 HD104418
6 · The paper itself

Abstract

Objective: Kisspeptin, encoded by the Methods: To evaluate the impact of IGF-1 on the metabolic and reproductive functions of kisspeptin producing cells, we created mice with IGF-1 receptor deletion driven by the Results: Loss of IGF1R in Conclusions: Overall, our study shows that IGF1R and IR in

Indexed as

Body weightIGF-1 receptorInsulin receptorKiss1-expressing cellsReproduction

Identifiers

PMID39005405
PMCPMC11244982

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.