ArticlebioRxiv : the preprint server for biology2025
A genome-wide association study implicates the olfactory system in
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The effects of environmental stress on animal life are gaining importance. Diapause is a reversible dormancy program triggered by adverse environmental conditions. To characterize the genetic basis of this complex program, we leveraged the Drosophila Genome Reference Panel (DGRP) to conduct a Genome-Wide Association Study (GWAS). We assessed post-diapause and non-diapause fecundity across 193 DGRP lines. GWAS revealed 546 variants, encompassing single nucleotide polymorphisms, insertions, and deletions associated with post-diapause fecundity. We identified 291 candidate diapause-associated genes, 40 of which were previously associated with diapause. Gene network analysis indicated that the diapause-associated genes were primarily linked to neuronal and reproductive system development. Similarly, comparison with other fly GWAS revealed the greatest overlap with olfactory-behavior-associated and fecundity-and-lifespan-associated genes. An RNAi screen of selected candidates identified two neuronal genes, Dip-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.