ArticleFrontiers in neurology2024
The relationship between obstructive sleep apnea and osteoarthritis: evidence from an observational and Mendelian randomization study.
Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep disturbances and sleep quality among individuals diagnosed with osteoarthritis: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Prevalence and impact of sleep disorders in osteoarthritis: A systematic review and meta-analysis.Osteoarthritis and cartilage open · 2026Article
- Association between body roundness index and obstructive sleep apnea: a cross-sectional study from the NHANES (2005-2008 to 2015-2020).BMC oral health · 2025Article
- Article
- Reduced Risk of Sleep Disturbance and Obstructive Sleep Apnea Following Joint Replacement in Osteoarthritis Patients.International journal of medical sciences · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Obstructive sleep apnea (OSA) and osteoarthritis (OA) are common comorbidities that significantly impact individuals' quality of life. However, the relationship between OSA and OA remains unclear. This study aims to explore the connection between OSA and OA and evaluate causality using Mendelian randomization (MR). Methods: A total of 12,454 participants from the National Health and Nutrition Examination Survey (2009-2012) were included. OSA participants were identified based on self-reported interviews. The association between OA and OSA was assessed through multivariable logistic regression analysis. A two-sample MR was employed to investigate the relationship between OSA and OA, specifically hip OA and knee OA, utilizing the inverse variance-weighted (IVW) approach. Results: Based on the observational study, individuals with OSA exhibited a higher risk of OA (OR = 1.67, 95% CI = 1.40-1.98). IVW demonstrated that the risk of OA (OR = 1.13, 95% CI: 1.05-1.21, Conclusion: The cross-sectional observational analysis unveiled noteworthy associations between OSA and OA. Meanwhile, findings from the MR study provide support for a causal role.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.