ReviewFrontiers in endocrinology2024
Fatty infiltration in the musculoskeletal system: pathological mechanisms and clinical implications.
Review in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Paraspinal muscle quality in chronic low back pain: a systematic review and meta-analysis of muscle atrophy and fat infiltration.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Pooled it
- Pooled it
- Myosteatosis and the survival of patients with hepatocellular carcinoma: a meta-analysis.Clinical and experimental medicine · 2025Pooled it
- The Combined Use of Hydroxymethylbutyrate and Branched-Chain Amino Acids to Counteract Uremic Sarcopenia.Nutrients · 2026Trial
- Article
- An Observational Study of Human Umbilical Cord Tissue Allografts for Paraspinal Muscle and Entheses Defects in the Thoracic and Lumbar Regions.Biomedicines · 2026Article
- Dyslipidemia is associated with abdominal fat depots but not with bone mineral density and muscle fat infiltration.Lipids in health and disease · 2026Article
- Automated CT-Based Muscle Density Predicts Mortality Regardless of Muscle Area.Journal of cachexia, sarcopenia and muscle · 2026Article
- Association between TMG-derived contractile muscle parameters and MRI-based muscle structure in sarcopenia.BMC musculoskeletal disorders · 2026Article
- Dietary inflammatory potential and physical activity adherence as synergistic predictors of systemic inflammation in post-myocardial infarction patients: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Comprehensive quantitative analysis of muscle cross-sectional area and intramuscular fat infiltration of hip using modified DIXON MRI based on chemical shift encoding technique.Frontiers in aging · 2026Article
- Article
- Deletion of an enhancer that controls Wnt gene expression following tissue injury produces increased adipogenesis in regenerated muscle.Development (Cambridge, England) · 2025Article
- 3D deep learning-based muscle volume quantification from thoracic CT as a surrogate for DXA-Derived appendicular muscle mass in older adults.Aging clinical and experimental research · 2025Article
- Transcriptional Study of Radiofrequency Device Using Experimental Mouse Model.International journal of molecular sciences · 2025Article
- A cross-sectional study on peroneal muscle echogenicity changes and their effects on balance functions in individuals with chronic ankle instability.Scientific reports · 2025Article
- NEDD4 enhances bone‑tendon healing in rotator cuff tears by reducing fatty infiltration.Molecular medicine reports · 2025Article
- Oestrogen suppresses the adipogenesis of fibro/adipogenic progenitors through reactivating the METTL3-ESR1-mediated loop in post-menopausal females.Clinical and translational medicine · 2025Article
- Muscle Fat Infiltration in Patients with Multiple Myeloma: A Case-Control Study.International journal of general medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty infiltration denotes the anomalous accrual of adipocytes in non-adipose tissue, thereby generating toxic substances with the capacity to impede the ordinary physiological functions of various organs. With aging, the musculoskeletal system undergoes pronounced degenerative alterations, prompting heightened scrutiny regarding the contributory role of fatty infiltration in its pathophysiology. Several studies have demonstrated that fatty infiltration affects the normal metabolism of the musculoskeletal system, leading to substantial tissue damage. Nevertheless, a definitive and universally accepted generalization concerning the comprehensive effects of fatty infiltration on the musculoskeletal system remains elusive. As a result, this review summarizes the characteristics of different types of adipose tissue, the pathological mechanisms associated with fatty infiltration in bone, muscle, and the entirety of the musculoskeletal system, examines relevant clinical diseases, and explores potential therapeutic modalities. This review is intended to give researchers a better understanding of fatty infiltration and to contribute new ideas to the prevention and treatment of clinical musculoskeletal diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.