Evidence map›Paper›PMID 39007757›Full record

ReviewClinical cancer research : an official journal of the American Association for Cancer Research2024

NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance.

Yvonne M Mowery, Jason J Luke

Abstract readReview
In one paragraph

Review in Clinical cancer research : an official journal of the American Association for Cancer Research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Gut · 2026
    Article
  8. Ionizing Radiation Induces Extracellular Trap Release from Macrophages.International journal of molecular sciences · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yvonne M MoweryUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.ORCID 0000-0002-9839-2414
Jason J LukeUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.ORCID 0000-0002-1182-4908

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Project 5: Microenvironment manipulation using anti-angiogenics to improve immunotherapy in melanomaP50CA254865 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, HONG · 2021 to 2025
$10.4M
NCI ET-CTN with Phase i Emphasis at UPCIUM1CA186690 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD, Farshid Dayyani · 2014 to 2026
$9.1M
Employing Novel Primary Mouse Models of Head and Neck Cancer to Overcome Chemoradiation ResistanceK08DE029887 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOWERY, YVONNE MARIE · 2020 to 2024
$804k
Damon Runyon Cancer Research Foundation (DRCRF) 712041National Institutes of Health (NIH) K08DE029887National Institutes of Health (NIH) UM1CA186690NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA254865NCI NIH HHS UM1 CA186690NIDCR NIH HHS K08 DE029887
6 · The paper itself

Abstract

Neutrophil extracellular trap (NET)osis via lytic neutrophil death or neutrophil activation is associated with standard cancer therapies, notably including radiotherapy; is immunosuppressive; and may enhance metastasis and treatment resistance. This emerging area of research should be prioritized in drug development and standard of care treatment paradigms including radiation therapy, chemotherapy, and immunotherapy. See related article by Teijeira et al., p. 4131.

Indexed as

Drug Resistance, NeoplasmExtracellular TrapsNeoplasmsNeutrophilsAnimalsHumansImmunotherapyNeutrophil ActivationTumor Microenvironment

Identifiers

PMID39007757
PMCPMC11398986

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.